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Sickle cell disease is a group of disorders that affects hemoglobin, the molecule in red blood cells that delivers oxygen to cells throughout the body. People with this disorder have atypical hemoglobin molecules called hemoglobin S, which can distort red blood cells into a sickle, or crescent, shape.
Signs and symptoms of sickle cell disease usually begin in early childhood. Characteristic features of this disorder include a low number of red blood cells (anemia), repeated infections, and periodic episodes of pain. The severity of symptoms varies from person to person. Some people have mild symptoms, while others are frequently hospitalized for more serious complications.
The signs and symptoms of sickle cell disease are caused by the sickling of red blood cells. When red blood cells sickle, they break down prematurely, which can lead to anemia. Anemia can cause shortness of breath, fatigue, and delayed growth and development in children. The rapid breakdown of red blood cells may also cause yellowing of the eyes and skin, which are signs of jaundice. Painful episodes can occur when sickled red blood cells, which are stiff and inflexible, get stuck in small blood vessels. These episodes deprive tissues and organs of oxygen-rich blood and can lead to organ damage, especially in the lungs, kidneys, spleen, and brain. A particularly serious complication of sickle cell disease is high blood pressure in the blood vessels that supply the lungs (pulmonary hypertension). Pulmonary hypertension occurs in about one-third of adults with sickle cell disease and can lead to heart failure.
Wiki User
∙ 13y ago
Wiki User
∙ 11y agoSickle cell anaemia is caused by a genetic mutation that affects the normal development of haemoglobin.
A genetic mutation is a permanent alteration in the normal pattern of DNA that makes up genes. Genes consist of coiled strands of DNA, and each cell contains the same genetic material.
Wiki User
∙ 9y agoBoth. Sickle cell anemia is a genetically controlled blood disease. Individuals that are heterozygous for the trait (Called Sickle-Cell Trait) have an advantage in regions of the world where malaria is endemic. These same individuals are at a disadvantage at high altitudes, during exertion and are subject to a number of issues that can result in strokes and kidney failure among other issues.
Individuals with two copies the sickle cell gene have Sickle-Cell Disease. There are significant health issues for affected individuals with a lifetime of treatment for pain and blood issues.
Wiki User
∙ 12y agoThe production of an abnormal type of hemoglobin
Wiki User
∙ 11y agoSickle cells can cause sickle cell anemia. This type of anemia is genetically transmitted, and it most common in people of African American ancestry.
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What poikilocytosis means?
Abnormal shape in RBC's Sickle Cell trait and disease will cause poikilocytic red blood cells.
Why do some people have different shaped red blood cells?
Some people have diseases, such as Sickle Cell Anemia. The disease makes a person's red blood cells in the shape of a sickle, hence the name, "Sickle" Cell Anemia. A normal person's red blood cell shape is round as opposed to the diseased person's red blood cell. It depends on the type of disease the person has. Some are round, some sickle shape, and others raisen-like (drained).
Is the disease genetic?
Familial Amyloid Polyneuropathy (FAN) or Corino de Andrade's disease, a form of Paramyloidosis, is a neurodegenerative autosomal dominant genetically transmitted disease, first identified and described by Portuguese neurologist Mário Corino da Costa Andrade, in the 1950s. It is a fatal and incurable disease. <><><><> In addition, Huntington's Disease and Sickle Cell Anemia are both genetically transmitted ailments.
What is the result of change in amino acid in hemoglobin?
Of course, there can be many outcomes from no problems to sickle cell disease to fetal death. Some mutations really cause no problems, some can cause a disease and some are so damaging it can cause the death of the unborn child.
How do you know you have Heart diseases?
High blood pressure, coronary artery disease, valvular heart disease, stroke, or rheumatic fever/rheumatic Heart disease can cause heart disease.
What disease arises from an amino acid change in the protein hemoglobin?
Sickle Cell disease A disease that involves misshaped cells that can easily cause blood clots.
What can cause a attack of sickle cell anemia?
Although sickle cell anemia(SS) and sickle cell disease(SC) are considered genetic mutations, I believe the question is...What are possible causes for a sickle cell attack? Anything that causes a constriction of the blood vessels would seem to be a cause. Smoking, coffee, and alcohol to name a few. Dehydration also appears to play a big role.
Can sickle cell cause high white blood cells?
Yes in sickl cell disease the white blood cell is
What poikilocytosis means?
Abnormal shape in RBC's Sickle Cell trait and disease will cause poikilocytic red blood cells.
Sickle cell disease?
Sickle cell anemia or sickle cell disease (SCD)is genetic health disorder of your red blood cells (RBCs). Usually, Red blood cells are in shape of a disc which gives them full freedom to travel via even smallest blood vessels in the body. However, with this disorder, the red blood cells shape abnormally like a crescent shape resembling a tool called sickle. This makes these red blood cells sticky & rigid prone to likely getting trapped in the small vessels which partially blocks or stops the blood from reaching different parts of your body. This condition can cause pain and damage of tissues.
What hereditary red blood cell disorders may cause hemolysis?
There are many genetic mutations that affect the hemoglobin itself, the best-known of which is sickle cell disease. Such hereditary disorders as spherocytosis weaken the outer membrane of the red cell.
Can a blood transfusion cause hemophilia?
No. Hemophilia is a genetic disease. But many hemophiliacs can benefit from having them.
What is the description and cause of sickle cell disease?
Not sure
Does sickle cell disease cause stroke?
Approximately 11% of individuals with sickle cell disease will have a recognizable stroke by the age of 20
What does poikilocytosis mean?
Having poikilocytes in your blood - which are irregular red blood cells
Can sickle cell's kill you?
a possible way it can kill you is from a simple blood clot. If the sickle shaped blood cells that formed into clumps stick to the walls of the blood vessels, blood flow will be blocked and the lack of blood circulation can cause a blood clot. If that blood clot so happens to follow the blood stream into your heart... YOU WILL DIE.
How do you get sickle cell disease?
You can prevent sickle cell disease by theres no way you can but if you have sickle cell disease you can get blood transfusions to stop most of the pain becasue you can get new blood cells instead of moon like shaped cells and then you will have easier blood flow and no pain because it wont clog anymore.
