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In the major pathway of ethanol metabolism the 2 enzymes involved are alcohol dehydrogenase, aldehyde dehydrogenase and thiokinase.

ethanol + NAD+ <=> acetaldehyde + NADH + H+ (ethanol dehydrogenase)

acetaldehyde + NAD+ <=> acetate + NADH + H+ (aldehyde dehydrogenase)

acetate + coA + ATP <=> acetyl coA + AMP + PPi (thiokinase)

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