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Marie's scientific studies began with the research of a phenomenon for which she later coined the word "radioactivity". Marie worked jointly with Pierre and Henri Becquerel, a French scientist, and in 1903 they shared the Nobel Prize in Physics due to their work with radioactive material and the discovering of its properties. Today radioactivity is used in cancer treatments, molecular Biology, modern genetics, as well as the dating of artifacts.

Marie also discovered polonium, which was named after her native land of Poland, and radium in 1898, chemicals which she devoted the rest of her life to studying. Marie discovered how to isolate these elements so that they might be used for useful causes, such as cancer therapy. In addition, she won the Nobel Prize in Chemistry in 1911 for discovering the method used to isolate pure radium. Marie also developed a process called Curietherapy with the help of Pierre, a process that was used to treat malignant tumors at the time.

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