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What is the P53 gene function?
p53 is a gene that codes for a protein (p53) that is an important tumor suppressor. Although the number of pathways and roles of p53 continue to expand it is, perhaps, most well known for slowing cell proliferation or inducing apoptosis if DNA damage or uncontrolled growth is detected.
What type of gene is the p53 gene?
p53 (also known as protein 53 or tumor protein 53), is a tumor suppressor protein that in humans is encoded by the TP53gene. p53 is crucial in multicellular organisms, where it regulates the cell cycle and, thus, functions as a tumor suppressorthat is involved in preventing cancer. As such, p53 has been described as "the guardian of the genome" because of its role in conserving stability by preventing genome mutation.The name p53 is in reference to its apparent molecular mass: It runs as a 53-kilodalton (kDa) protein on SDS-PAGE. But, based on calculations from its amino acid residues, p53's mass is actually only 43.7 kDa. This difference is due to the high number of prolineresidues in the protein, which slows its migration on SDS-PAGE, thus making it appear heavier than it actually is. This effect is observed with p53 from a variety of species, including humans, rodents, frogs, and fish..
What is the role of the transactiovation domain of p53?
The transactivation domain of p53 is responsible for activating the transcription of genes involved in cell cycle regulation, DNA repair, and apoptosis. It interacts with transcriptional coactivators and the basal transcription machinery to promote the expression of these genes in response to cellular stress or damage.
Why is p53 important?
p53 is a crucial tumor suppressor protein that plays a vital role in maintaining genomic stability. It regulates the cell cycle, promotes DNA repair, and can initiate apoptosis in response to cellular stress or DNA damage. By preventing the proliferation of potentially cancerous cells, p53 acts as a guardian of the genome, making it essential for cancer prevention and the overall maintenance of cellular integrity. Mutations in the p53 gene are commonly found in various cancers, highlighting its importance in tumorigenesis.
Why p53 is run as 53 kda on sds page?
p53 is detected as approximately 53 kDa on SDS-PAGE because it is a 53 kilodalton (kDa) protein. SDS-PAGE separates proteins based on size, so the molecular weight of p53 corresponds to the band observed at 53 kDa on the gel.
How many copies of the p53 gene do humans have?
Humans typically have two copies of the p53 gene.
What has the author Gerard P Zambetti written?
Gerard P. Zambetti has written: 'The p53 tumor suppressor pathway and cancer' -- subject(s): P53 antioncogene, P53 protein
What does 'p53-proficient mean?
'P53-proficient' refers to cells or organisms that possess a functional p53 protein, which plays a crucial role in regulating the cell cycle, DNA repair, and apoptosis (programmed cell death). P53 is often termed the "guardian of the genome" because it helps prevent the proliferation of cells with damaged DNA, thereby acting as a tumor suppressor. In contrast, 'p53-deficient' indicates a loss or mutation of the p53 gene, which can lead to increased risk of cancer development.
How many copies of the p53 gene do average humans have?
Most average humans have two copies of the p53 gene.
How many copies of p53 genes do average humans typically have?
Most average humans have two copies of the p53 gene.
Is p53 a protein?
Yes, p53 is a protein that plays a crucial role in regulating cell growth and preventing tumor formation.
What cancers does the p53 cancer gene cause?
P53 it is an anzyme that monitorize the DNA and protect them from demagis.It is founded that its defective in 60% of cancer cells
A cell with a defective p53 gene is likely to?
A defective P53 gene is likely to cause poor regulation of cell cycles. P53 is a protein that suppresses tumor production and is implicated as a factor in cancer development. It prevents genome mutation and damage. 50% of human tumors have mutated or deleted P53 genes.
What is p53 called?
"The Guardian Angel Gene"
Who identified the p53 gene?
The p53 gene was identified by a team of researchers led by Dr. David Lane and Dr. Arnold Levine in 1979. The protein encoded by the p53 gene plays a critical role in suppressing tumor formation and is often referred to as the "guardian of the genome."
What is the P53 gene function?
p53 is a gene that codes for a protein (p53) that is an important tumor suppressor. Although the number of pathways and roles of p53 continue to expand it is, perhaps, most well known for slowing cell proliferation or inducing apoptosis if DNA damage or uncontrolled growth is detected.
What is the role of P53 in Cell Cycle Check Point?
The p53 Tumour suppressor gene is located on chromosome 17. As its name suggests, it has an anti-tumour activity. That involves the overseeing of the cell cycle. If either the cell or the DNA is impaired, p53 activates the production of specific chemicals (like p21 protein), which interferes with the cell cycle. Depending on the nature/extent of the damage, its either repaired, thus cell cycle is allowed to continue, or p53 initiate apoptosis (cell death). This mechanism would effectively stop the proliferation of infected (malignant) cells, however, p53 itself (or any of genes/chemicals p53 regulates) could be damaged/mutated. In the inherited condition, Li-Fraumeni syndrome, for example, only one functional copy of p53 gene is inherited (instead of two), which interferes with its normal function.
