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p53 is a gene that codes for a protein (p53) that is an important tumor suppressor. Although the number of pathways and roles of p53 continue to expand it is, perhaps, most well known for slowing cell proliferation or inducing apoptosis if DNA damage or uncontrolled growth is detected.
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What type of gene is the p53 gene?
p53 (also known as protein 53 or tumor protein 53), is a tumor suppressor protein that in humans is encoded by the TP53gene. p53 is crucial in multicellular organisms, where it regulates the cell cycle and, thus, functions as a tumor suppressorthat is involved in preventing cancer. As such, p53 has been described as "the guardian of the genome" because of its role in conserving stability by preventing genome mutation.The name p53 is in reference to its apparent molecular mass: It runs as a 53-kilodalton (kDa) protein on SDS-PAGE. But, based on calculations from its amino acid residues, p53's mass is actually only 43.7 kDa. This difference is due to the high number of prolineresidues in the protein, which slows its migration on SDS-PAGE, thus making it appear heavier than it actually is. This effect is observed with p53 from a variety of species, including humans, rodents, frogs, and fish..
What is p53 marker?
p53 is a protein that acts as a tumor suppressor, helping to prevent the formation of cancerous tumors. It is often used as a marker for cancer because mutations in the p53 gene are commonly found in various types of cancer cells. Detection of p53 abnormalities can help with cancer diagnosis and prognosis.
What is P53 and what does it have to do with cancer?
The human gene known as p53 is a tumor suppressor gene and malfunctions of it have been implicated in many cancer types. Research is using it to study the biology of cancer, as well as to develop new drug targets to cure certain cancers.In 1993, p53 protein was named Molecule of the Year by Science magazine. It is a protein that is very important for the regulation of cell cycles in humans and other multi-cellular organisms. p53 is also known as TP53 and several other names including tumor protein (EC :2.7.1.37), the "guardian of the genome", and the "Guardian Angel Gene" (because it works to prevent mutation or damage to the genome).Most recent genetic research is also promising in the search for cancer causes and treatments. The research indicates there is a relationship between development of cancer and insufficiency of the p53 gene.More than 50% of the tumors in humans show a mutation of or deletion of this gene. It is believed that various things can cause the mutations or damage/deletion of p53, such as DNA damage from chemicals, UV ray damage, and there are some known viruses that can inhibit the function of p53, such as Simian Virus 40 (SV40) and Human Papillomavirus (HPV), an STD.These viruses and DNA damage can inactivate p53, rendering it ineffective for tumor suppression.See more in related questions and links.
What is gene symbol?
A gene symbol is a standardized abbreviation used to represent a specific gene in scientific literature and databases. It typically consists of a combination of letters and numbers, reflecting the gene's name or function, and is often used for ease of reference. For example, the gene symbol "TP53" refers to the tumor protein p53 gene, which is crucial in regulating the cell cycle and preventing cancer. These symbols are maintained by organizations like the HUGO Gene Nomenclature Committee (HGNC) to ensure consistency and clarity in genetic research.
Why is p53 important?
p53 is a crucial tumor suppressor protein that plays a vital role in maintaining genomic stability. It regulates the cell cycle, promotes DNA repair, and can initiate apoptosis in response to cellular stress or DNA damage. By preventing the proliferation of potentially cancerous cells, p53 acts as a guardian of the genome, making it essential for cancer prevention and the overall maintenance of cellular integrity. Mutations in the p53 gene are commonly found in various cancers, highlighting its importance in tumorigenesis.
How can one repair the p53 gene effectively?
Repairing the p53 gene effectively can be achieved through gene therapy techniques, such as using CRISPR-Cas9 to correct mutations in the gene. This approach involves precise editing of the gene to restore its normal function, which can help in treating diseases associated with p53 gene mutations.
How many copies of the p53 gene do humans have?
Humans typically have two copies of the p53 gene.
How many copies of the p53 gene do average humans have?
Most average humans have two copies of the p53 gene.
What is p53 called?
"The Guardian Angel Gene"
Who identified the p53 gene?
The p53 gene was identified by a team of researchers led by Dr. David Lane and Dr. Arnold Levine in 1979. The protein encoded by the p53 gene plays a critical role in suppressing tumor formation and is often referred to as the "guardian of the genome."
How many copies of p53 genes do average humans typically have?
Most average humans have two copies of the p53 gene.
Is the p53 gene under expressed or over expressed in li-fraumeni?
In Li-Fraumeni syndrome, the p53 gene is typically mutated rather than simply under-expressed or over-expressed. These mutations lead to a loss of function of the p53 protein, which normally plays a crucial role in regulating the cell cycle and preventing tumor formation. As a result, individuals with Li-Fraumeni syndrome have an increased risk of developing various cancers due to the compromised tumor-suppressing capabilities of p53.
What cancers does the p53 cancer gene cause?
P53 it is an anzyme that monitorize the DNA and protect them from demagis.It is founded that its defective in 60% of cancer cells
A cell with a defective p53 gene is likely to?
A defective P53 gene is likely to cause poor regulation of cell cycles. P53 is a protein that suppresses tumor production and is implicated as a factor in cancer development. It prevents genome mutation and damage. 50% of human tumors have mutated or deleted P53 genes.
What role does p53 have in controlling cell division?
Cell division is regulated by the p53 gene and relates to cancer because Cancer is caused by uncontrolled cell divison
What happens if gene p53 is suppressed?
When you fire it the bullet will make less noise.
Is there a gene related to colon or rectal cancer?
In patients with colon or rectal cancer, the p53 gene is mutated 70% of the time
