p53 is a gene that codes for a protein (p53) that is an important tumor suppressor. Although the number of pathways and roles of p53 continue to expand it is, perhaps, most well known for slowing cell proliferation or inducing apoptosis if DNA damage or uncontrolled growth is detected.
p53 (also known as protein 53 or tumor protein 53), is a tumor suppressor protein that in humans is encoded by the TP53gene. p53 is crucial in multicellular organisms, where it regulates the cell cycle and, thus, functions as a tumor suppressorthat is involved in preventing cancer. As such, p53 has been described as "the guardian of the genome" because of its role in conserving stability by preventing genome mutation.The name p53 is in reference to its apparent molecular mass: It runs as a 53-kilodalton (kDa) protein on SDS-PAGE. But, based on calculations from its amino acid residues, p53's mass is actually only 43.7 kDa. This difference is due to the high number of prolineresidues in the protein, which slows its migration on SDS-PAGE, thus making it appear heavier than it actually is. This effect is observed with p53 from a variety of species, including humans, rodents, frogs, and fish..
p53 is a protein that acts as a tumor suppressor, helping to prevent the formation of cancerous tumors. It is often used as a marker for cancer because mutations in the p53 gene are commonly found in various types of cancer cells. Detection of p53 abnormalities can help with cancer diagnosis and prognosis.
The human gene known as p53 is a tumor suppressor gene and malfunctions of it have been implicated in many cancer types. Research is using it to study the biology of cancer, as well as to develop new drug targets to cure certain cancers.In 1993, p53 protein was named Molecule of the Year by Science magazine. It is a protein that is very important for the regulation of cell cycles in humans and other multi-cellular organisms. p53 is also known as TP53 and several other names including tumor protein (EC :2.7.1.37), the "guardian of the genome", and the "Guardian Angel Gene" (because it works to prevent mutation or damage to the genome).Most recent genetic research is also promising in the search for cancer causes and treatments. The research indicates there is a relationship between development of cancer and insufficiency of the p53 gene.More than 50% of the tumors in humans show a mutation of or deletion of this gene. It is believed that various things can cause the mutations or damage/deletion of p53, such as DNA damage from chemicals, UV ray damage, and there are some known viruses that can inhibit the function of p53, such as Simian Virus 40 (SV40) and Human Papillomavirus (HPV), an STD.These viruses and DNA damage can inactivate p53, rendering it ineffective for tumor suppression.See more in related questions and links.
The first gene name in a gene sequence typically refers to the first gene identified or annotated within a specific genomic context. However, without specific context or a reference genome, it is impossible to determine an exact gene name, as gene sequences vary widely across different organisms and individual genomes. In general, gene names often follow conventions based on the organism, function, or other characteristics, such as "TP53" for the tumor protein p53 gene in humans. To identify the first gene in a particular sequence, one would need to analyze that specific genomic data.
p53 is a tumor suppressor gene that helps to control cell growth and prevent cancer development. It plays a critical role in protecting cells from DNA damage by either repairing the damage or inducing cell death if the damage is severe. When activated, p53 can signal for cell cycle arrest, DNA repair, or apoptosis (programmed cell death) to eliminate cells with irreparable damage.
Repairing the p53 gene effectively can be achieved through gene therapy techniques, such as using CRISPR-Cas9 to correct mutations in the gene. This approach involves precise editing of the gene to restore its normal function, which can help in treating diseases associated with p53 gene mutations.
Humans typically have two copies of the p53 gene.
Most average humans have two copies of the p53 gene.
"The Guardian Angel Gene"
The p53 gene was identified by a team of researchers led by Dr. David Lane and Dr. Arnold Levine in 1979. The protein encoded by the p53 gene plays a critical role in suppressing tumor formation and is often referred to as the "guardian of the genome."
Most average humans have two copies of the p53 gene.
P53 it is an anzyme that monitorize the DNA and protect them from demagis.It is founded that its defective in 60% of cancer cells
A defective P53 gene is likely to cause poor regulation of cell cycles. P53 is a protein that suppresses tumor production and is implicated as a factor in cancer development. It prevents genome mutation and damage. 50% of human tumors have mutated or deleted P53 genes.
When you fire it the bullet will make less noise.
Cell division is regulated by the p53 gene and relates to cancer because Cancer is caused by uncontrolled cell divison
In patients with colon or rectal cancer, the p53 gene is mutated 70% of the time
because, usually it is a defect in a tumor suppressing gene such as p53.