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The human gene known as p53 is a tumor suppressor gene and malfunctions of it have been implicated in many cancer types. Research is using it to study the Biology of cancer, as well as to develop new drug targets to cure certain cancers.
In 1993, p53 protein was named Molecule of the Year by Science magazine. It is a protein that is very important for the regulation of cell cycles in humans and other multi-cellular organisms. p53 is also known as TP53 and several other names including tumor protein (EC :2.7.1.37), the "guardian of the genome", and the "Guardian Angel Gene" (because it works to prevent mutation or damage to the genome).
Most recent genetic research is also promising in the search for cancer causes and treatments. The research indicates there is a relationship between development of cancer and insufficiency of the p53 gene.
More than 50% of the tumors in humans show a mutation of or deletion of this gene. It is believed that various things can cause the mutations or damage/deletion of p53, such as DNA damage from chemicals, UV ray damage, and there are some known viruses that can inhibit the function of p53, such as Simian Virus 40 (SV40) and Human Papillomavirus (HPV), an STD.
These viruses and DNA damage can inactivate p53, rendering it ineffective for tumor suppression.
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What is p53 marker?
p53 is a protein that acts as a tumor suppressor, helping to prevent the formation of cancerous tumors. It is often used as a marker for cancer because mutations in the p53 gene are commonly found in various types of cancer cells. Detection of p53 abnormalities can help with cancer diagnosis and prognosis.
What type of gene is the p53 gene?
p53 (also known as protein 53 or tumor protein 53), is a tumor suppressor protein that in humans is encoded by the TP53gene. p53 is crucial in multicellular organisms, where it regulates the cell cycle and, thus, functions as a tumor suppressorthat is involved in preventing cancer. As such, p53 has been described as "the guardian of the genome" because of its role in conserving stability by preventing genome mutation.The name p53 is in reference to its apparent molecular mass: It runs as a 53-kilodalton (kDa) protein on SDS-PAGE. But, based on calculations from its amino acid residues, p53's mass is actually only 43.7 kDa. This difference is due to the high number of prolineresidues in the protein, which slows its migration on SDS-PAGE, thus making it appear heavier than it actually is. This effect is observed with p53 from a variety of species, including humans, rodents, frogs, and fish..
What is the P53 gene function?
p53 is a gene that codes for a protein (p53) that is an important tumor suppressor. Although the number of pathways and roles of p53 continue to expand it is, perhaps, most well known for slowing cell proliferation or inducing apoptosis if DNA damage or uncontrolled growth is detected.
What is p53 and how does it work?
p53 is a tumor suppressor gene that helps to control cell growth and prevent cancer development. It plays a critical role in protecting cells from DNA damage by either repairing the damage or inducing cell death if the damage is severe. When activated, p53 can signal for cell cycle arrest, DNA repair, or apoptosis (programmed cell death) to eliminate cells with irreparable damage.
Can you explain the way an abnormal p53 causes normal cells to become cancer cells?
Abnormal p53 can lead to uncontrolled cell growth because it is unable to properly regulate the cell cycle or initiate cell death (apoptosis) in response to DNA damage or other cellular stressors. This can allow damaged cells to proliferate and accumulate mutations, ultimately leading to the development of cancer.
What is p53 marker?
p53 is a protein that acts as a tumor suppressor, helping to prevent the formation of cancerous tumors. It is often used as a marker for cancer because mutations in the p53 gene are commonly found in various types of cancer cells. Detection of p53 abnormalities can help with cancer diagnosis and prognosis.
What cancers does the p53 cancer gene cause?
P53 it is an anzyme that monitorize the DNA and protect them from demagis.It is founded that its defective in 60% of cancer cells
What has the author Gerard P Zambetti written?
Gerard P. Zambetti has written: 'The p53 tumor suppressor pathway and cancer' -- subject(s): P53 antioncogene, P53 protein
What role does p53 have in controlling cell division?
Cell division is regulated by the p53 gene and relates to cancer because Cancer is caused by uncontrolled cell divison
Is there a gene related to colon or rectal cancer?
In patients with colon or rectal cancer, the p53 gene is mutated 70% of the time
Why is cancer a genetic disorder?
because, usually it is a defect in a tumor suppressing gene such as p53.
A cell with a defective p53 gene is likely to?
A defective P53 gene is likely to cause poor regulation of cell cycles. P53 is a protein that suppresses tumor production and is implicated as a factor in cancer development. It prevents genome mutation and damage. 50% of human tumors have mutated or deleted P53 genes.
What are the effects of hot spots in p53 protein structure?
Hot spots in p53 protein structure are critical residues that are involved in protein-protein interactions or binding with other molecules. Mutations in these hot spots can disrupt the function of p53, leading to loss of its tumor-suppressing abilities and potentially contributing to cancer development. Understanding and targeting these hot spots can be crucial for developing therapies to restore p53 function in cancer treatment.
How do viruses cause cancer?
In your cell you have cancer suppressors such as the P53 or the ASP proteins that when they have genetic mutations of tumor cells they will stop the cell cycle. Viruses stop the Rb protein and the P53 so that the cell goes on creating "viral genetic code" like a normal virus does but doesn't know its causing cancer because the cell genome in unstable. cancer results.
What type of gene is the p53 gene?
p53 (also known as protein 53 or tumor protein 53), is a tumor suppressor protein that in humans is encoded by the TP53gene. p53 is crucial in multicellular organisms, where it regulates the cell cycle and, thus, functions as a tumor suppressorthat is involved in preventing cancer. As such, p53 has been described as "the guardian of the genome" because of its role in conserving stability by preventing genome mutation.The name p53 is in reference to its apparent molecular mass: It runs as a 53-kilodalton (kDa) protein on SDS-PAGE. But, based on calculations from its amino acid residues, p53's mass is actually only 43.7 kDa. This difference is due to the high number of prolineresidues in the protein, which slows its migration on SDS-PAGE, thus making it appear heavier than it actually is. This effect is observed with p53 from a variety of species, including humans, rodents, frogs, and fish..
What is the P53 gene function?
p53 is a gene that codes for a protein (p53) that is an important tumor suppressor. Although the number of pathways and roles of p53 continue to expand it is, perhaps, most well known for slowing cell proliferation or inducing apoptosis if DNA damage or uncontrolled growth is detected.
If p53 is a tumor suppressor gene why can it not stop cancer?
It may be able to once more research and testing is done. It has been shown, however, that just supplementing or replacing the damaged P53 can not be effectively used yet to suppress tumors since that would cause premature aging.
