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80S ribosomes are inhibited by a number of agents. Some are differential inhibitors 80S ribosomes (found in eukaryotic cells) and 70S Ribosomes (found in prokaryotic cells and mitochondria. Among them are:

Cycloheximide (CAS 66-81-9): Inhibits peptidyl transferase activity of the 80S ribosomes, with comparatively little effect on 70S ribosomal function

Ricin (CAS 9009-86-3) is a very powerful inhibitor of protein synthesis in 80S ribosomes, and it's reported to be irreversible. Ricin is extremely toxic and is considered a weapon-making material.

α-sarcin (CAS 86243-64-3) cleaves a ribosomal RNA on 80S ribosomes.

Other inhibitors of 80S ribosomes include Shiga-like toxin Stx2; Abrin (CAS 1393-62-0).

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14y ago

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