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A nucleic acid always contains sugar molecules, phosphate groups, and nitrogen bases. A single nucleotide contains one sugar molecule, one phosphate group, and one nitrogen base. A DNA nucleotide contains one deoxyribose sugar molecule, one phosphate group, and one nitrogen base, which could be any of the following: adenine, thymine, guanine, or cytosine. An RNA nucleotide contains one ribose sugar molecule, one phosphate group, and one nitrogen base, which could be any of the following: adenine, uracil, guanine, or cytosine.

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