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Postganglionic fibers innervate glands in the body primarily through the autonomic nervous system, specifically the sympathetic and parasympathetic divisions. These fibers originate from autonomic ganglia and connect to target tissues, including glands, often by traveling alongside spinal nerves. In the case of sympathetic innervation, postganglionic fibers may follow blood vessels or directly innervate glands like the adrenal medulla. In contrast, parasympathetic fibers arise from cranial nerves and sacral spinal nerves, directly influencing glands such as salivary and lacrimal glands.

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