Who discovered proteasomes?

Answer 1

Proteasomes were discovered by researchers who were studying protein degradation within cells. The key discovery came in the 1980s by a group led by Aaron Ciechanover, Avram Hershko, and Irwin Rose, who identified the ubiquitin-mediated proteolysis pathway and elucidated the role of proteasomes in protein breakdown. Their work laid the foundation for understanding how cells regulate protein levels and maintain cellular function. In 2004, the trio was awarded the Nobel Prize in Chemistry for their contributions to this field.