In medical terms, one might speak of the course of a disease, or its natural history. For instance, multiple sclerosis may take a relapsing/remitting course, or a progressive course.
Course may also refer to a period of medication. Someone may be prescribed a course of oral prednisone, for instance, to help with an exacerbation of Asthma.
The word meaning "rough" is spelt coarse. The word meaning "line of orientation" is spelt course.
Sauce
Advice
Not together. The word "of" can be used as a preposition. However, the idiomatic construction "of course" is a compound adverb meaning "certainly" or definitely.
That is the spelling of the noun "course" meaning a path or pathway, as in plotting a course, playing a golf course, or a course of action. The homophone is the adjective "coarse" meaning rough, not smooth, or unpolished. The idiom "course close to my heart" is not a standard idiom. Perhaps the word sought is "source" (an origin or beginning point).
No. It can only be a preposition. The idiomatic form "of course" is an adverb meaning certainly or surely.
The Italians of course! Spaghetti comes from the word spago meaning string. Spaghetti describes the plural and smaller form of the word.
The line is "Stand you directly in Antonius' way when he doth run his course" and is said by Caesar to his wife Calpurnia. Antony is one of the men running in the footrace which is traditional on the Lupercal celebrations. The word "course" has the same meaning as in the expressions "race course" or "golf course"; it is the path which the contestants have to follow. To run his course is to run the race along the prescribed path.
Using a noun : empire-building Using an economic activity : colonialism Of course imperialism is already one word.
Synonyms are words that have the same or nearly the same meaning.
determination; maintain a course of action; failure to stop implementation of present circumstances
Flamenco is already a Spanish word, meaning 'flamingo'. It is also, of course, a kind of dance.