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You can take the Downtown 1 train (of the 1-2-3,the red line) from 42nd Street-Times Square (at 7th Avenue) to Canal Street (at Varick Street). This station is on the West Side of Manhattan.

Or, you can take the Downtown N-R-Q-W (the yellow line) from 42nd Street-Times Square to Canal Street (at Broadway). This stop is further east than the Canal Street Station on the 1train. It will drop you off pretty much exactly in the center of Manhattan.

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