To get from Penn Station to 622 Third Avenue, you can take the 1, 2, or 3 subway lines from 34th Street-Penn Station to Times Square-42nd Street. From there, transfer to the 7 train and head to Grand Central-42nd Street. Once at Grand Central, it's a short walk to 622 Third Avenue.
You don't have to take the subway; it's 2 blocks. Penn Station is at 34th Street between 8th and 7th Avenues, and 520 8th Avenue is between 36th and 37th Streets.
Take the Uptown E train (of the A-C-E, the blue line) from 34th Street-Penn Station to 53rd Street-5th Avenue. Fifth Avenue is one block west of Madison Avenue.
In Penn Station, NYC, you can catch the subway by following the signs to the subway entrance, which is located on the lower levels of the station. The main access points are typically found at 7th Avenue and 8th Avenue. Look for the entrances marked with the subway logo, and you can access lines such as the A, C, E, 1, 2, and 3 trains. Be sure to check the signs for the specific route you need.
Park Avenue is about half a mile east of Penn Station.
Take the Downtown 1 train (of the 1-2-3, the red line), 1 stop, from 34th Street-Penn Station to 28th Street (at 7th Avenue).
You don't need to take the subway to get from Penn Station to 28th Street and 8th Avenue (which is in the Chelsea neighborhood, by the way, not in Greenwich Village or Greenwich Connecticut). Penn Station is at 34th Street between 8th and 7th Avenues. So you can just walk there.
To travel from LaGuardia Airport to Penn Station using the train, you can take the Q70-SBS bus from the airport to the Jackson Heights-Roosevelt Avenue subway station. From there, you can transfer to the E train, which will take you directly to Penn Station.
To take the subway from LaGuardia to Penn Station, you will need to first take the Q70 bus from the airport to the Roosevelt Ave-Jackson Heights subway station. From there, you can transfer to the E train, which will take you directly to Penn Station.
Walk west to Lexington Avenue and north to 53rd Street, and take the Downtown E train (of the A-C-E, the blue line) from Lexington Avenue-53rd Street to 34th Street-Penn Station.
To travel from LaGuardia Airport to Penn Station using the subway, you can take the M60 bus from the airport to the Astoria Blvd subway station. From there, you can transfer to the N or W train and take it to 34th Street-Herald Square station, which is near Penn Station.
Take the Uptown E train (of the A-C-E, the blue line) from 34th Street-Penn Station to 5th Avenue-53rd Street. Then walk 2 blocks south on 5th Avenue to St. Patrick's (on 5th Avenue between 51st and 50th Streets).