You have several options. Which one to choose depends upon which part of the Bronx you are going to. See the Related Link below for a complete New York City subway map.
Option 1: The 2 trainYou can take the Uptown 2 train (of the 1-2-3, the red line) straight from 34th Street-Penn Station to the Bronx.
Option 2: The 5 trainTake the Uptown 2 train from 34th Street-Penn Station to 3rd Avenue-149th Street, and transfer there to the Uptown 5train.
Option 3: The 4 or 5 trainsTake the Uptown 2 train from 34th Street-Penn Station to 149th Street-Grand Concourse, and transfer there to the Uptown 4 or 5.
Option 4: The 6 trainTransfer is not available from the 2 train to the 6 train, so if the 6 train is the closest train to your destination, then you will have to take the Uptown 2train from 34th Street-Penn Station to 149th Street-Grand Concourse, and transfer there to the Downtown 4 or 5. Take the Downtown 4 or 5 to 125th Street in Manhattan, and transfer at 125th Street to the Uptown 6train.
You could also take the Uptown 1-2-3, one stop, from 34th Street-Penn Station to 42nd Street-Times Square, and transfer there to the S shuttle train (color grey) east across 42nd Street, from Times Square (West 42nd) to Grand Central Station (East 42nd). Then, either transfer at Grand Central to the Uptown 6(which is a local train) or transfer to the Uptown 4 or 5 express trains to 125th Street, and then transfer at 125th Street to the Uptown 6.
Although the first option requires you to go Uptown, then Downtown, then back Uptown again, it will still probably take less time than the second option. The 6 is a local train, so there are many, many stops from Grand Central Station to the Bronx. As mentioned above, you can transfer at Grand Central to the Uptown 4 and 5 express trains to 125th, and then transfer at 125th to the Uptown 6. But then you'll have to make three transfers. The first option requires you to make only two transfers.
Option 5: The B or D trainsTake the Uptown A or C trains (of the A-C-E, the blue line) from 34th Street-Penn Station to 59th Street-Columbus Circle, and transfer there to the Uptown Bor D trains (of the B-D-F-M, the orange line).
3 uptown, transfer to S, then 6.
To travel from Penn Station to 851 Grand Concourse in the Bronx, take the 2 subway line from 34th Street-Penn Station station towards Wakefield-241st Street. Transfer at the 149th Street-Grand Concourse station to the 4 or 5 line, and then continue to the 167th Street station. From there, it's a short walk to your destination at 851 Grand Concourse.
To take the subway from LaGuardia to Penn Station, you will need to first take the Q70 bus from the airport to the Roosevelt Ave-Jackson Heights subway station. From there, you can transfer to the E train, which will take you directly to Penn Station.
You take the subway to New York City Penn Station. Then you get on a Northeastern Regional train going south to Philadelphia. Trains leave Penn Station regularly.
To travel from LaGuardia Airport to Penn Station using the subway, you can take the M60 bus from the airport to the Astoria Blvd subway station. From there, you can transfer to the N or W train and take it to 34th Street-Herald Square station, which is near Penn Station.
No, the AirTrain takes you to and from the subway, and the subway takes you to and from Penn Station. Take the AirTrain to the Howard Beach Station, and get the Manhattan-bound A train (of the A-C-E, the blue line) to 34th Street-Penn Station.
No, but it does stop at penn station and you can take the subway
Take the Uptown E train (of the A-C-E, the blue line) from 34th Street-Penn Station to Court Square.
To get from Penn Station to Worth Street, you can take the 1 subway line. Board the 1 train at 34th Street-Penn Station and travel downtown. Get off at the Chambers Street station, which is close to Worth Street. Alternatively, you could take the A or C train from 34th Street-Penn Station to Chambers Street for a similar route.
To get to the Hayden Planetarium from Penn Station, take the A, C, or E subway line from 34th Street-Penn Station. Transfer at 42nd Street-Port Authority Bus Terminal to the 1 subway line, then travel uptown to 79th Street. From there, it's a short walk to the American Museum of Natural History, where the Hayden Planetarium is located.
To navigate from Penn Station to Battery Park using the subway system, you can take the 1 train from Penn Station towards South Ferry. Get off at the South Ferry station, which is the closest stop to Battery Park. From there, you can walk to Battery Park.
You don't need to take the subway to get from Penn Station to 28th Street and 8th Avenue (which is in the Chelsea neighborhood, by the way, not in Greenwich Village or Greenwich Connecticut). Penn Station is at 34th Street between 8th and 7th Avenues. So you can just walk there.