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The development of Islam in the 7th century significantly impacted Constantinople's influence on Christianity by shifting the religious and political landscape in the region. As Islamic empires expanded, they challenged Byzantine authority and diminished its role as the central hub of Christianity. This led to a fragmentation of Christian unity, as various factions emerged, including the Eastern Orthodox Church, which became more autonomous in response to Islamic pressures. Consequently, Constantinople's position as the predominant Christian center weakened, paving the way for the rise of other influential Christian centers in Europe.

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