First, a local anesthetic is applied at the four sites where the frame's pins contact the head; there may nonetheless be some initial discomfort.
On the day of the surgery, the stereotactic frame will be fixed to the patient's head.
A final MRI is done with the frame in place to help set the coordinates of the GPi in relation to the frame.
This device is a rigid frame attached to the patient's head, providing an immobile three-dimensional coordinate system, which can be used to precisely track the location of the GPi and the movement of the probe.
Pallidotomy is performed in the hospital by a neurosurgeon, in coordination with the patient's neurologist.
To destroy tissue in the GPi, a long needle-like probe is inserted deep into the brain, through a hole in the top of the skull. To make sure the probe reaches its target exactly, a rigid "stereotactic frame" is attached to the patient's head.
Some centers perform pallidotomy as an outpatient procedure, sending the patient home the same day. Most centers keep the patient overnight or longer for observation.
The patient will receive a mild sedative to ease the anxiety of the procedure.
Patients will feel improved movement immediately.
During the procedure, the patient will be asked to make various movements to assist in determining the location of the electrode.
Medications may be adjusted somewhat to accommodate the changes in symptoms.
In addition, the patient must remain awake in order to report any sensory changes during the surgery.
Pallidotomy is performed in patients with Parkinson's disease who are still responsive to levodopa, but who have developed disabling drug treatment complications known as motor fluctuations.