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Cystic Fibrosis

An inherited disease affecting exocrine glands and resulting in chronic infections in the respiratory system and faulty pancreatic function.

454 Questions

Is it possible for a mother to have two kids with different father be born with cystic fibrosis?

Depends. If your mother has cystic fibrosis and your father is a carrier, there is a 50% chance that any of their children will have cystic fibrosis. If the father is not a carrier, no children will have cystic fibrosis, but they will all be carriers.

How are cells affected by cystic fibrosis?

Cystic fibrosis affects the epithelium which is one of the four most basic types of tissue in animals. Chloride and sodium don't properly move across the cells producing a thick, sticky substance.

Are pulmonary fibrosis and cystic fibrosis related?

Asthma is a reactive airway disease. The lining of the bronchi and bronchiloli the smaller airways get inflamed and swell and the muscular lining of the airways spasm causing shortness of breath. It can be triggered by emotion and enviornmental allergens as well as other things like aspirating foreign objects (think little tiny bits of water etc). The cause of cystic fibrosis is a lack of a gene sequence that causes the airways to be clogged with thick gunky secretions. You can test for this disease now really easily so that you will not accidently give it to your kids. It also affects the sodium levels in the body and the ability to absorb nutrients. Kids with CF are constantly needing to have their lungs cleaned out by postural drainage (hanging upside down and being patted hard on the back or "percussed") and a one of my friends grandkids ended up with double lung transplants, one lived and one died. Another friend of mine managed to live to the age of 35 with the disease, though toward the end his ability to breathe was gone and he basically suffocated.

How can a child have cystic fibrosis?

Cystic Fibrosis cannot be prevented. It is an inherited disease, so there is no possible way to prevent something inherited. One parent will be a carrier and so will the other parent, therefore resulting in the child having CF.

What is the genotype of two normal parents who have a child with cystic fibrosis?

The genotype would have to be homozygous recessive if the child was completely effected by the disease. The "normal" paretns would have to have heterozygous recessive genotypes. This makes sense since the allele that causes sickle cell shows incomplete dominance when present with a normal allele in a pair. The "normal" parents actually would have a mixture of sickle cell shaped red blood cells combined with normal shaped ones. The carrier parents does not display symptoms of the disease since the regular red blood cells alone can fill the body's need for oxygen under normal circumstances. The only time the cArrier would notice would be under times of extreme oxygen demand, such as a sprint.

Can an Adult get cystic fibrosis?

From what I understand there is no such thing as Adult Onset Cystic Fibrosis. CF is a hereditary genetic disease that you are born with. That said, there are rare cases of people with symptoms so mild they were not diagnosed until there 30s-60s. Sometimes these people have had prior medical problems but their doctors didn't check for CF because of their age. It is often so debilitating that children are diagnosed within the first few days of life. I am not an expert, I am just looking for research because I was told to go in for a test today (at age 33). The hospital couldn't even administer the test in the normal lab, I need to go to the children's hospital. I am just now reading http://www.cff.org/ it has more official information.

How is cystic fibrosis caused?

1. Cystic fibrosis is caused by recessive inheritance as is sickle cell disease, Tay Sachs, Phenylketonuria, Thalassemia, and Galactosemia.

(i got that ot of the book)

Cystic Fibrosis is caused by a genetic mutation.

Will the offspring have cystic fibrosis if the mother is FF and father is Ff?

No. Cystic fibrosis is an autosomal recessive disease. Each parent would have to be a carrier of a CF mutation and would be Cc.

What two parts of the body are affected by cystic fibrosis?

cystic fibrosis means there is too much fluid in the lungs and it makes it very hard for them to breathe. It also affects their growing and their digestive system because of the mucus. Unfortunately even a small cold can make them very sick because it affects the lungs. Unfortunately they usually die in their 30's and it is a very serious disease that more people need to be educated about.

Who is the oldest person living with cystic fibrosis?

That changes often as people die, but in general the data (as of 2014) had the oldest CF patient in the US as 82, in England as 79, and in Ireland, as 78.

Can cystic fibrosis gene be inherited from one parent?

For a baby to be born with Cystic Fibrosis, both parents must be carriers of the faulty CF gene. Where both parents carry the faulty gene, each child has a one in four chance of having CF, a two in four chance of being a carrier and a one in four chance of not having any CF genes.

How can one child be born healthly and second one have cystic fibrosis?

To have a child with cystic fibrosis both parents must be a carrier or a sufferer. A carrier is a person who has one healthy gene, and one diseased gene, so they dont have cystic fibrosis but they can pass it on to their children.

Children inherit one gene from each parent. To get cystic fibrosis a child must get two copies of the 'disease' gene - one from each parent. If two carriers have children, each child has a 25% chance not getting a Cystic fibrosis disease gene, 50% of being a carrier and 25% of being a sufferer. This is not affected by if the child is male or female. So essentially the answer is bad luck.

How disorder is inherited cystic fibrosis?

Cystic Fibrosis, is a recessive disease (meaning that both parents must be carriers of the cystic fibrosis gene, for the offspring to have a chance of being born with it).

A child has a 25% chance (1/4) of being born with Cystic Fibrosis.

What cells are affected by cystic fibrosis?

The protein affected by cystic fibrosis is called the cystic fibrosis transmembrane conductance regulator or CFTR. CFTR acts as a channel that transports negatively charged chloride ions into and out of cells. This helps control the flow of water in tissues. CFTR also regulates the function of other channels that transport positive sodium ions into and out of cells.

How many copies of an allele need to be present for someone to have cystic fibrosis?

Both cystic fibrosis and sickle cell anemia are single mutation diseases - one mutation in a single gene is enough to cause the disease. However, for cystic fibrosis both alleles of the gene must be mutated for the disease to develop. For sickle cell anemia, only one allele can carry the mutation and some signs of the disorder will be present. Having two alleles with the mutation causes much more significant disease.

Does cystic fibrosis affect males or females more?

There is an even distribution between males and females however the effects of cystic fibrosis effect them differently. Unfortunately the majority of males are infertile but women have more of a chance to conceive.

What are the chances of having cystic fibrosis if your sibling has it?

Well color really doesnt matter. what matters is the genetics. If you would like to find out if your child is a carrier you would have to get found out by going to the doctor they can help you figure that out by doing a test. But For your child to have CF you or your mate must be a carrier.

What is perihilar fibrosis?

i think is fibrosis at the space between portal vein and central vein (pass into hepatic vein)

What is survival rate for Cystic Fibrosis?

Cystic Fibrosis is a life threatening genetic disorder. More children are living into adulthood with better treatment options. The death rate is 100 percent, when the lungs and pancreas quit functioning.

Can someone aged 78 have cystic fibrosis?

It is extremerly unlikely, nearly a definite no as without medical help, the life expectancy of a suffer is only a few months after they were born and even with medical help, the most a cycstic fibrosis suffer is looking at is 40 years at the most.

Is cystic fibrosis more common in a certain population or ethnicity of people?

Yes. Cystic fibrosis is an inherited chronic disease that affects the lungs and digestive system of about 30,000 children and adults in the United States (70,000 worldwide). A defective gene and its protein product cause the body to produce unusually thick, sticky mucus that:

* clogs the lungs and leads to life-threatening lung infections; and

* obstructs the pancreas and stops natural enzymes from helping the body break down and absorb food.

What is derma fibrosis?

Derma fibrosis refers to skin fiber.

If both parents have cystic fibrosis what is the probability that one child will have it?

It depends weather or not the woman carries the cystic fibrosis alele.

If she carries a recessive CF allele, then the chances of her and the man having a child with CF is 1/4

But if she doesn't carry it then the child wont have CF but could carry the disorder as a recessive allele. again, the chances of that are 1/4.