73 miles taking this route:

1. Follow U.S. 441 SOUTH from Lady Lake to SR-46 to MT. DORA and SANFORD. EXIT.
2. Turn left off the exit ramp, then take SR-46 EAST to I-4. At JCT I-4, follow signg to I-4 EAST.
3. Take I-4 EAST to Daytona Beach.

810 miles taking this route:

1. Take I-95 NORTH, from Daytona Beach to I-10 WEST via I-295 NORTH to bypass JACKSONVILLE (EXIT 337 off I-95 to get onto I-295, follow signs to I-295 NORTH ; EXIT 21B off I-295 to get onto I-10 WEST to LAKE CITY).
2. Take I-10 WEST to I-75 NORTH to VALDOSTA at EXIT 296B, near Lake City.
3. Take I-75 NORTH to I-20 WEST to BIRMINGHAM, via I-475 NORTH (EXIT 156 off I-75 in GEORGIA) to bypass MACON and I-285 WEST ATLANTA BYPASS (EXIT 238B off I-75 in GEORGIA to get onto I-285 WEST BYPASS ; EXIT 10B off I-285 to get onto I-20 WEST to BIRMINGHAM).
4. Take I-20 WEST to U.S. 78 to JASPER at EXIT 123 in BIRMINGHAM, ALABAMA ; turn right off the exit ramp onto U.S. 78 WEST.
5. Take U.S. 78 (FUTURE I-22) to Memphis.

The approximate driving time and mileage information -

Between: Destin, FL

and: Daytona Beach, FL

Driving miles: 410

Driving time: 7 hrs

- is based on traveling non-stop in good driving conditions. Driving time does not take into consideration conditions which may extend travel time such as weather, road work, border crossings, and rush hour traffic in urban areas. Mileage denotes actual road miles covered as opposed to Point A to Point B linear distances on a map.