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Huntington's Disease

Huntington’s disease is a hereditary disorder that destroys certain areas of the brain involved in intellect, emotion, and movement development. It is characterized by the loss of mental abilities; developing of emotional problems; and uncontrollable movement of the limbs and face.

237 Questions

How many people in the US have huntingtons disease?

Huntington's disease affects approximately 30,000 people in the United States, with an additional 200,000 at risk of inheriting the condition. The disease is caused by a genetic mutation and typically manifests in adulthood. Its prevalence is about 5 to 10 cases per 100,000 people in the general population.

Why does Huntingtons often go undiagnosed?

Huntington's disease often goes undiagnosed because its symptoms can be subtle and may resemble other psychiatric or neurological conditions, leading to misdiagnosis. Additionally, the disease typically manifests in mid-adulthood, meaning that individuals may not seek evaluation until they experience more pronounced symptoms. Genetic testing is required for a definitive diagnosis, but not everyone with a family history of Huntington's chooses to undergo testing due to potential psychological and social implications.

What cells are damaged in huntington's disease and where in the brain are they located?

In Huntington's disease, the primary cells that are damaged are neurons, particularly in the basal ganglia, with a significant focus on the striatum, which includes the caudate nucleus and putamen. These areas of the brain are crucial for movement control and coordination. The degeneration of these neurons leads to the characteristic motor, cognitive, and psychiatric symptoms associated with the disease. Additionally, there is also some involvement of other brain regions, including the cerebral cortex.

What disorders are associate with the neurotransmitter GABA?

GABA (gamma-aminobutyric acid) is primarily associated with mood and anxiety disorders. Dysregulation of GABA can contribute to conditions such as generalized anxiety disorder, panic disorder, and depression. Additionally, low GABA levels are implicated in seizure disorders and certain types of neurodevelopmental disorders, including autism spectrum disorder. Overall, GABA's inhibitory role in the central nervous system is crucial for maintaining emotional and cognitive balance.

What is huntingtons first name?

Huntington's first name is "Huntington." The term commonly refers to Huntington's disease, which is named after Dr. George Huntington, who first described the condition in 1872. If you meant a specific individual with the surname Huntington, please provide more context.

What is the name of the genetic test for Huntington's disease so my doctor can order it?

The genetic test for Huntington's disease is commonly referred to as the "Huntington's disease genetic test" or "HTT gene testing." This test analyzes the CAG repeat expansion in the HTT gene on chromosome 4. If you're discussing this with your doctor, you can simply refer to it as the Huntington's disease genetic test, and they will know how to proceed with the ordering process.

What disease did he have?

I'm sorry, but I need more context to answer your question accurately. Could you specify who "he" is and provide any relevant details about the situation or individual?

What are the main features of huntingtons chorea?

Huntington's chorea, also known as Huntington's disease, is characterized by progressive motor dysfunction, including involuntary jerking or writhing movements (chorea), as well as cognitive decline and psychiatric symptoms. Patients often experience behavioral changes, mood swings, and difficulties with coordination and balance. The disease typically manifests in mid-adulthood and is caused by a genetic mutation in the HTT gene, leading to neurodegeneration, particularly in the basal ganglia. As the disease progresses, individuals may face significant challenges in daily functioning and require increasing levels of care.

Does Stephen Hawking have Huntington's disease?

In 1963, Hawking contracted motor neurone disease and was given two years to live.

Is huntington disease a autosomal dominant disorder?

Yes, Huntington's disease is an autosomal dominant disorder caused by a mutation in the HTT gene on chromosome 4. An affected individual has a 50% chance of passing on the mutated gene to each of their children.

Is huntington disease multifactorial inheritance?

No. It's an inherited disease. The gene is dominant so basically if you have it, 50% of your children will inherit it as well which can particularly devastating since the symptoms don't appear until the 30's or 40's. So theoretically you can have children that are teenagers by the time you find out, and 50% of them will become afflicted as well.

ERROR, each of your children has a 50% chance of inheriting the gene. ALSO, there is Jhd, where children can get it... usually when HD is inherited from the father... but not always. Children as young as 2 have been known to have it. Sadly I have known too many children to die of Jhd.

A woman heterozygous for Huntington disease reproduces with a man without the condition. What are the chances the child will have the condition?

There is a 50% chance that Mary's mother passed along her gene for HD. Since this cannot be "canceled out" by her father's unaffected genes, Mary has a 50% chance of having and expressing that bad gene. If Mary's father was also heterozygous for HD, there would be a 75% chance that she would get at least one bad gene.

To add the the answer above, Huntington's disease doesn't typically show itself until a person is between 35 to 50 years of age. The reason that the normal genes for the father don't "cancel out" any affected genes passed on my the mother is because this is a dominant genetic disorder
there are lots of diseases and they keep on being made. PS. stay safe and disease free.

When was the huntington disease found?

Huntington's disease was first described by American physician George Huntington in 1872. He published a paper detailing the symptoms and progression of the disease in several generations of a family living in Long Island, New York.

Where is Huntington disease found in the body?

Huntington's disease primarily affects the brain. It is a neurodegenerative disorder that causes the progressive breakdown of nerve cells in the brain. Symptoms typically include movement disorders, cognitive decline, and psychiatric disturbances.

Total how many diseases are in the world?

Animals can get all the different types of diseases that humans get. Broadly speaking, this includes bacterial infections, viral infections, parasite infestations, fungal infections, cancer, degenerative diseases, metabolic conditions and congenital defects.

What does a lack of chromosomes do?

well you see is when you have lake of chromezome you are not in the good and give to the poor for money if only you can show it for money so, when to tell you is then give me some for ill open it and show it okay

Did Rosa have a disease?

Rosa Parks did not have a specific disease. She was known for her pivotal role in the civil rights movement in the United States, particularly for her refusal to give up her seat to a white passenger on a public bus in Montgomery, Alabama in 1955.

Is there a particular group more likely to get Huntington disease?

Huntington disease is an inherited condition, so those with a family history of the disease are more likely to develop it. It affects people of all ethnicities and genders equally. Symptoms usually appear in adulthood, but can manifest at any age.

Is huntington disease homozygous or heterozygous?

Huntington disease is autosomal dominant, meaning that individuals who inherit one copy of the mutant allele from either parent will develop the disease. Thus, individuals with Huntington's disease are heterozygous for the mutant allele. Homozygous individuals would not survive past a certain age due to the severity of the disorder.

Disease protist and what it does?

One example of a disease-causing protist is Plasmodium, which causes malaria. Plasmodium is transmitted to humans through the bite of infected Anopheles mosquitoes and infects red blood cells, leading to symptoms such as fever, chills, and anemia. If left untreated, malaria can be life-threatening.

What is Caeliac disease?

It is a disease where the body can't digest gluten. Gluten is commonly found in wheat and other products. A person eating gluten can experience bloating, upset stomach, gastric pain, vomiting, diarrhea.

Why does huntington disease persist as a degenerative genetic disorder?

Several reasons. Until a few years ago, there WAS no genetic screening possible for HD- only when symptoms developed could the disease be diagnosed. Symptoms typically appeared between 30-40 years of age- AFTER people had already had children. As a result, a new generation of Huntington's patients would be born before the parents knew that THEY had HD.

What disease can cause by anger?

Chronic anger or anger-related lifestyle factors can contribute to a range of health issues such as high blood pressure, heart disease, weakened immune system, and increased risk of stroke. It can also negatively impact mental health, leading to anxiety, depression, and unhealthy coping mechanisms like substance abuse.

Causes of endocrine disease?

Endocrine diseases can be caused by various factors, including genetics, autoimmune conditions, tumors affecting the endocrine glands, infections, and lifestyle factors such as diet and exercise. Hormonal imbalances, disruptions in feedback loops, and malfunctions in specific endocrine glands can also lead to endocrine diseases.

What are the symptoms of Huntington disease?

There are three things tha are controlled in Huntington's Disease, those being: Movement, Congitive, and Psychatritc.

Movement:

  • Clumsiness
  • Jaw clenching (bruxism)
  • Loss of coordination and balance
  • Slurred speech
  • Swallowing and/or eating difficulty
  • Uncontrolled continual muscular contractions (dystonia)
  • Walking difficulty, stumbling, falling

Psychiatric:

  • Hostility/irritability
  • Inability to take pleasure in life (anhedonia)
  • Lack of energy

Huntington's disease is a rare disease that affects the brain. It destroys the victims mind and body. It's caused by a dominant gene. The signs of Huntington's disease rarely show up early in life. The disease usually doesn't strike before the age of 40. By the time a person, who has the gene may have already had children and passed on the deadly gene to them. For along time, there was no way to test for the gene before the disease developed. You can't get rid of it.