Huntington's Disease

Huntington's disease (HD) is an autosomal dominant genetic disorder, meaning that individuals with one copy of the mutated gene will develop the disease. There are no true "carrier forms" of HD, as those who carry the mutated gene will eventually manifest symptoms, typically in mid-adulthood. However, individuals can be asymptomatic for a period, but they still possess the gene and can pass it on to their offspring. Lethal forms of HD are not recognized; rather, the disease progresses over time, leading to severe disability and ultimately death, often 15 to 20 years after the onset of symptoms.

Huntington's disease affects approximately 30,000 people in the United States, with an additional 200,000 at risk of inheriting the condition. The disease is caused by a genetic mutation and typically manifests in adulthood. Its prevalence is about 5 to 10 cases per 100,000 people in the general population.

Huntington's disease often goes undiagnosed because its symptoms can be subtle and may resemble other psychiatric or neurological conditions, leading to misdiagnosis. Additionally, the disease typically manifests in mid-adulthood, meaning that individuals may not seek evaluation until they experience more pronounced symptoms. Genetic testing is required for a definitive diagnosis, but not everyone with a family history of Huntington's chooses to undergo testing due to potential psychological and social implications.

In Huntington's disease, the primary cells that are damaged are neurons, particularly in the basal ganglia, with a significant focus on the striatum, which includes the caudate nucleus and putamen. These areas of the brain are crucial for movement control and coordination. The degeneration of these neurons leads to the characteristic motor, cognitive, and psychiatric symptoms associated with the disease. Additionally, there is also some involvement of other brain regions, including the cerebral cortex.

GABA (gamma-aminobutyric acid) is primarily associated with mood and anxiety disorders. Dysregulation of GABA can contribute to conditions such as generalized anxiety disorder, panic disorder, and depression. Additionally, low GABA levels are implicated in seizure disorders and certain types of neurodevelopmental disorders, including autism spectrum disorder. Overall, GABA's inhibitory role in the central nervous system is crucial for maintaining emotional and cognitive balance.

Huntington's first name is "Huntington." The term commonly refers to Huntington's disease, which is named after Dr. George Huntington, who first described the condition in 1872. If you meant a specific individual with the surname Huntington, please provide more context.

The genetic test for Huntington's disease is commonly referred to as the "Huntington's disease genetic test" or "HTT gene testing." This test analyzes the CAG repeat expansion in the HTT gene on chromosome 4. If you're discussing this with your doctor, you can simply refer to it as the Huntington's disease genetic test, and they will know how to proceed with the ordering process.

I'm sorry, but I need more context to answer your question accurately. Could you specify who "he" is and provide any relevant details about the situation or individual?

Huntington's chorea, also known as Huntington's disease, is characterized by progressive motor dysfunction, including involuntary jerking or writhing movements (chorea), as well as cognitive decline and psychiatric symptoms. Patients often experience behavioral changes, mood swings, and difficulties with coordination and balance. The disease typically manifests in mid-adulthood and is caused by a genetic mutation in the HTT gene, leading to neurodegeneration, particularly in the basal ganglia. As the disease progresses, individuals may face significant challenges in daily functioning and require increasing levels of care.

In 1963, Hawking contracted motor neurone disease and was given two years to live.

Yes, Huntington's disease is an autosomal dominant disorder caused by a mutation in the HTT gene on chromosome 4. An affected individual has a 50% chance of passing on the mutated gene to each of their children.

No. It's an inherited disease. The gene is dominant so basically if you have it, 50% of your children will inherit it as well which can particularly devastating since the symptoms don't appear until the 30's or 40's. So theoretically you can have children that are teenagers by the time you find out, and 50% of them will become afflicted as well.

ERROR, each of your children has a 50% chance of inheriting the gene. ALSO, there is Jhd, where children can get it... usually when HD is inherited from the father... but not always. Children as young as 2 have been known to have it. Sadly I have known too many children to die of Jhd.

Huntington's disease was first described by American physician George Huntington in 1872. He published a paper detailing the symptoms and progression of the disease in several generations of a family living in Long Island, New York.

Huntington's disease primarily affects the brain. It is a neurodegenerative disorder that causes the progressive breakdown of nerve cells in the brain. Symptoms typically include movement disorders, cognitive decline, and psychiatric disturbances.

Animals can get all the different types of diseases that humans get. Broadly speaking, this includes bacterial infections, viral infections, parasite infestations, fungal infections, cancer, degenerative diseases, metabolic conditions and congenital defects.

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Rosa Parks did not have a specific disease. She was known for her pivotal role in the civil rights movement in the United States, particularly for her refusal to give up her seat to a white passenger on a public bus in Montgomery, Alabama in 1955.

Huntington disease is an inherited condition, so those with a family history of the disease are more likely to develop it. It affects people of all ethnicities and genders equally. Symptoms usually appear in adulthood, but can manifest at any age.

Huntington disease is autosomal dominant, meaning that individuals who inherit one copy of the mutant allele from either parent will develop the disease. Thus, individuals with Huntington's disease are heterozygous for the mutant allele. Homozygous individuals would not survive past a certain age due to the severity of the disorder.

One example of a disease-causing protist is Plasmodium, which causes malaria. Plasmodium is transmitted to humans through the bite of infected Anopheles mosquitoes and infects red blood cells, leading to symptoms such as fever, chills, and anemia. If left untreated, malaria can be life-threatening.

It is a disease where the body can't digest gluten. Gluten is commonly found in wheat and other products. A person eating gluten can experience bloating, upset stomach, gastric pain, vomiting, diarrhea.

Several reasons. Until a few years ago, there WAS no genetic screening possible for HD- only when symptoms developed could the disease be diagnosed. Symptoms typically appeared between 30-40 years of age- AFTER people had already had children. As a result, a new generation of Huntington's patients would be born before the parents knew that THEY had HD.

Chronic anger or anger-related lifestyle factors can contribute to a range of health issues such as high blood pressure, heart disease, weakened immune system, and increased risk of stroke. It can also negatively impact mental health, leading to anxiety, depression, and unhealthy coping mechanisms like substance abuse.

Endocrine diseases can be caused by various factors, including genetics, autoimmune conditions, tumors affecting the endocrine glands, infections, and lifestyle factors such as diet and exercise. Hormonal imbalances, disruptions in feedback loops, and malfunctions in specific endocrine glands can also lead to endocrine diseases.