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Thalassemia
Thalassemia is an inherited blood disorder wherein the body forms abnormal hemoglobin – the protein in the red blood cells carrying oxygen. This disorder leads to excessive destruction of red blood cells, which results in anemia.
107 Questions
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If one parent has beta thalassemia what are the chances the baby will inherit the condition?
If one parent is a carrier then the baby has a 50% chance of being born a carrier as well, but the baby will be healthy as the gene is recessive.
Can a silent carrier of alpha-thalassemia ever have macrocytes?
Yes, a silent carrier of alpha-thalassemia can have macrocytes, although it is not common. Macrocytosis typically occurs when there is an underlying deficiency in vitamin B12 or folate, but it can also be seen in some cases of thalassemia due to ineffective erythropoiesis. In silent carriers, the impact on red blood cell morphology is usually mild, but variations can occur based on individual genetic and environmental factors. Regular monitoring and further testing are advised if macrocytic anemia is suspected.
Difference between thalassemia and sickle cell anemia?
Thalassemia is a genetic disorder as a result of an imbalance in the hemoglobin. In sickle cell, also a genetic disorder, the mutation cause a crescent shaped molecule.
