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Thalassemia
Thalassemia is an inherited blood disorder wherein the body forms abnormal hemoglobin – the protein in the red blood cells carrying oxygen. This disorder leads to excessive destruction of red blood cells, which results in anemia.
107 Questions
Where did the different types of Alpha- Thalassemia in the population come from?
Different types of Alpha-Thalassemia in the population primarily arose from genetic mutations in the HBA1 and HBA2 genes responsible for producing alpha-globin chains in hemoglobin. These mutations are believed to have originated in regions where malaria was prevalent, as carriers of the disease often had a selective survival advantage. Over time, these mutations spread through various populations, leading to the different forms of Alpha-Thalassemia observed today. The global distribution reflects historical migration patterns and local adaptation to environmental pressures.
How do I know that my thalassemia is minor or major?
there is a test by which u can know ur status u go to Dr. lal lab and asc for thalassemia test if u got minor then when u going to marry or going to making baby please make check up of ur life mate if they also thalassssemia minor don't be marry or make baby because ur baby may be thalassemia major
Should you take iron if you have thalassemia minor?
Most doctors are befuddled about thal minor and give few if any recommendations. Often, doctors mistakenly prescribe iron supplements when they see the low hematocrit level. However, unless iron deficiency coincides with the thal minor, iron will not help and long term usage when not needed can cause problems, including damage to organs. Iron deficiency should be verified through iron studies, which include the serum ferritin test, before iron supplements are ever taken.
Thal minors need to try to optimize their health through diet, supplements and exercise. Minors have very little of the margin of error that non-thals have and have to pay close attention to maintaining good health. Folic acid should be taken by all thal carriers, minor through major. B-complex vitamins can also help energy levels and are needed to build red blood cells. Vitamin E is a good antioxidant that helps protect red blood cells. Magnesium and vitamin D are also of great interest to all thals. Wheatgrass in any of its forms, juice, tablets or extract, may help to raise fetal hemoglobin levels and also improve the immune system and overall energy levels.
Overall its okay to eat foods that have iron in it but, do not take iron supplement.
If you have beta thalassemia trait and your partner has sickle cell trait there is a 25% chance of your child having sickle beta thalassemia.
Why does symptoms of beta thalassemia doesn't appear at birth?
Symptoms of beta thalassemia major or Cooley's anemia don't appear at birth because babies still have what is known as the fetal hemoglobin, which consists of two alpha chains and two delta chains, but the baby has no beta chains and therefore protected from the disorder. The baby will eventually develop the beta chains though.
Will the child be free from thalassemia if you are alpha and father is beta thalassemia trait?
have seen one of my friends sister had kid and all normal no complications...not thalassemia either.........beta and alpha i think there is 25% normal chance
What is the disease that prevents the body from producing red blood cells?
Pernicious Anemia has a lot to do with the red blood cells. You could do a search on the condition to see if this is what you're looking for.
Can you have both alpha thalassemia and beta thalassemia?
Of coare yes. You can get any hemoglobinopathy from a parent without any connection to other hemoglobinopathy (or any other hereditary disease) from the other parent.
Prof. Kornfeld Pal
Can a paternity test be negative because of beta thalassemia?
No as it's unrelated to the cells carrying the DNA code, which are the White Blood cells.
What do you do if you love someone and both of you have the thalassemia minor trait?
I knew that I have this trait but loved a girl who was incidently found to be a carrier when she got prgnant after our marriage. Any we got a haematologist's cosult and on his prescription my wife went under investigation for baby in her womb. And with 3rd baby al-hamdu-li-Allah all are normal for tests and one boy 7years and a girl 2years are active and healthy. Third one to be born in feb. 2005. Inshallah. I think this should be kept in mind that woman has to go under painful procedures and if Allah forbid baby is abnormal(ie Thalassemia Major) he or she has to be terminated before 12 week of gestational age to avoid the misserable life later on.For that you ought to be bold if you dare to marry. Happy marriage.
I am 34 year old software professional. I never had any problem thalassemia before. It is not even in my family. Suddenly I found that My blood parameter looks ab normal ( see below). Any comment?
Hb A 90.8%
Hb A2 7%
Hb F 2.2% RBC count 6.23 million/cu mm
Haemoglobin 12.8 g/dl
Haematocrit[PCV] 38.2%
MCV 61.3 fl
MCH 20.5 pg
MCHC 33.5 g/dl
Platelet count 179000 /cu.mm
You need to be checked for appendicitis The above answer is a good one, but also colon problems (spastic colon) can cause this as well as bacteria or parasites. It's best to see your doctor and they will give you something to take a stool sample in and off to the lab. It may also be a nervous stomach or an inflamed duodenum or, simply trapped gas. Still, see your doctor.
What is Thalassemia Intermediate?
A condition intermediate between the major and minor forms. Affected individuals can often manage a normal life but may need occasional transfusions, e.g., at times of illness or pregnancy, depending on the severity of their anemia.
Does thalassemia minor cause dizziness?
Yes. Thalassemia minor can cause someone to be anemic (reduced hemoglobin concentration or red blood cell count). One of the many symptoms of anemia is vertigo or dizziness.
Most people with thalassemia minor do not exhibit symptoms. Typically, differences can only be perceived when engaging in strenuous activities or exercise. There is currently no 'recommended' treatment for thalassemia minor because of this, but prescription medications, genetic therapies, or blood transfusions can be pursued if symptoms worsen.
If you go to the doctor for this, expect to have another blood test to reassess your Complete Blood Count (CBC) which is a basic lab test for anemic individuals.
NOTE: Thalassemia minor can severely worsen in pregnant women, who may need to take Iron/Folate/Vitamin B12 supplements.
What is the difference between thalassemia and sickle cell anemia?
Though Thalassemia and Sickle Cell Anemia are seemingly similar to the unknowing, a large difference remains; Thalassemia is characterized by a reduced production from one of the globin chains which make up hemoglobin while in Sickle Cell Anemia, the globin chains themselves are structurally defective.
The related links contain the best information I could find.
Id like to know this aswel. Does anyone know please?
Are there other names for Thalassemia disease?
- Alpha thalassemia silent carrier
- Alpha thalassemia minor, also called alpha thalassemia trait
- Hemoglobin H disease
- Alpha thalassemia major, also called hydrops fetalis
- Beta thalassemia minor, also called beta thalassemia trait
- Beta thalassemia intermedia
- Beta thalassemia major, also called Cooley's anemia or beta-zero (ß0) thalassemia
- Beta-plus (ß+) thalassemia
- Mediterranean anemia
What are the symptoms of thalassemia?
Symptoms of thalassemia include bone deformities in the face, fatigue, jaundice, stunted growth, shortness of breath, poor vision and enlarged spleen.
Why does thalassemia crew cut skull deformity?
Increased erythropoesis causes bone marrow expansion in the skull.
There are many reasons why you could have stomach pain on your right side including appendicitis. Appendicitis is the swelling and irritation of the appendix.
What to do when your stomach hurts?
If you're sure that this pain isn't major and it's not a medical emergency, here are some tips you can take to reduce or eliminate the pain.
1) Go to the bathroom. Even if you don't have the 'urge', your body knows that when you're there, it's time for it to get rid of what it no longer needs. Your stomachache could be anything from constipation to gas. Even if it's not, having too much food in your stomach does cause stomach pain, and going to the restroom can help speed up the digestion process. Even if you don't think it's working, repeat this step several times every fifteen minutes or so.
2) Lay down. While this might seem cliche, resting is a good way for your body to focus on the pain and help reduce it.
3) Lower stress. If there's something that's not very active that you enjoy, like reading, watching television, or playing a computer game, do it. It lowers stress, which could be causing tension and pain, and it will give you a chance to forget about the pain in your stomach.
4) If you need to vomit, vomit. If your body wants to expel something from your stomach, let it do so. If you're pretty sure that you're going to vomit, hang out by a toilet or other area where you will be able to vomit and easily clean up the mess. Stay away from smells that might upset your stomach further, like cooking food. If your trash bag has a scent, it may upset your stomach more.
Be sure that your pain isn't a medical emergency, and if the pain doesn't go away for a long period of time, get medical help.
4)
Is there a relation between Lupus and Beta Thalassemia Minor?
I have reason, though unscientific, to believe there may be a connection. Beta-Thalassemia minor is diagnosed in my family (myself, my children, and sporadic occurrences in older relatives), the older relatives first were diagnosed with lupus, had no idea they carried the BTM genetic disorder until a younger member was diagnosed and they were subsequently tested.
(medicine) A hereditary form of hemolytic anemia resulting from a defective synthesis of hemoglobin: thalassemia major is the homozygous state accompanied by clinical illness, and thalassemia minor is the heterozygous state and may not have evident clinical manifestations. Also known as Mediterranean anemia.
