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Can person that have hemoglobin e trait marry with a beta thalassemia carrier?
Yes, a person with hemoglobin E trait can marry a beta thalassemia carrier. However, it is important for both individuals to undergo genetic counseling to understand the potential risks for their children. They could have offspring with various combinations of hemoglobin disorders, including hemoglobin E disease or beta thalassemia. Genetic testing can help assess the likelihood of these outcomes.
Can mild thalassemia be a major thalassemia?
No. A minor form of the blood disorder thalassemia is when you inherited just one beta thalassemia gene, along with a normal beta-chain gene. This manifests as mild anaemia with a slight lowering of the hemoglobin level in the blood. No treatment is require. By contrast, a thalassemia major, also known as Cooley's Disease, is when one is born with two genes for beta thalassemia and no normal beta-chain gene. This is a serious disorder.
What mutations does beta-thalassemia have on DNA?
Beta-thalassemia is typically caused by mutations in the HBB gene located on chromosome 11. Common mutations include point mutations, deletions, or insertions in the HBB gene, leading to reduced or absent production of beta-globin chains in hemoglobin. These mutations disrupt the normal structure and function of hemoglobin, resulting in anemia and other symptoms associated with beta-thalassemia.
What are the different types of sickle cell disease and how do they differ from each other?
There are several types of sickle cell disease, including sickle cell anemia, sickle beta thalassemia, and sickle cell-hemoglobin C disease. These types differ based on the specific genetic mutations that affect the hemoglobin protein in red blood cells. Sickle cell anemia is the most common and severe form, where individuals have two copies of the sickle cell gene. Sickle beta thalassemia and sickle cell-hemoglobin C disease are milder forms that result from different combinations of genetic mutations. Symptoms and complications can vary among the different types of sickle cell disease.
Are there other names for Thalassemia disease?
Alpha thalassemia silent carrierAlpha thalassemia minor, also called alpha thalassemia traitHemoglobin H diseaseAlpha thalassemia major, also called hydrops fetalisBeta thalassemia minor, also called beta thalassemia traitBeta thalassemia intermediaBeta thalassemia major, also called Cooley's anemia or beta-zero (ß0) thalassemiaBeta-plus (ß+) thalassemiaMediterranean anemia
What does thallassemia mean?
Thalassemia describes a group of inherited disorders characterized by reduced or absent amounts of hemoglobin, the oxygen-carrying protein inside the red blood cells. There are two basic groups of thalassemia disorders: alpha thalassemia and beta thalassemia. These conditions cause varying degrees of anemia, which can range from insignificant to life threatening. Go to: http://medical-dictionary.thefreedictionary.com/Thallassemia
Why does symptoms of beta thalassemia doesn't appear at birth?
Symptoms of beta thalassemia major or Cooley's anemia don't appear at birth because babies still have what is known as the fetal hemoglobin, which consists of two alpha chains and two delta chains, but the baby has no beta chains and therefore protected from the disorder. The baby will eventually develop the beta chains though.
Is Beta Thalassemia fatal?
People whose hemoglobin does not produce enough beta protein have beta thalassemia. It is found in people of Mediterranean descent, such as Italians and Greeks, and is also found in the Arabian Peninsula, Iran, Africa, Southeast Asia and southern China.There are three types of beta thalassemia that also range from mild to severe in their effect on the body.Thalassemia Minor or Thalassemia Trait. In this condition, the lack of beta protein is not great enough to cause problems in the normal functioning of the hemoglobin. A person with this condition simply carries the genetic trait for thalassemia and will usually experience no health problems other than a possible mild anemia. As in mild alpha thalassemia, physicians often mistake the small red blood cells of the person with beta thalassemia minor as a sign of iron-deficiency anemia and incorrectly prescribe iron supplements.Thalassemia Intermedia. In this condition the lack of beta protein in the hemoglobin is great enough to cause a moderately severe anemia and significant health problems, including bone deformities and enlargement of the spleen. However, there is a wide range in the clinical severity of this condition, and the borderline between thalassemia intermedia and the most severe form, thalassemia major, can be confusing. The deciding factor seems to be the amount of blood transfusions required by the patient. The more dependent the patient is on blood transfusions, the more likely he or she is to be classified as thalassemia major. Generally speaking, patients with thalassemia intermedia need blood transfusions to improve their quality of life, but not in order to survive.Thalassemia Major or Cooley's Anemia. This is the most severe form of beta thalassemia in which the complete lack of beta protein in the hemoglobin causes a life-threatening anemia that requires regular blood transfusions and extensive ongoing medical care. These extensive, lifelong blood transfusions lead to iron-overload which must be treated with chelation therapy to prevent early death from organ failure.From Jagadish
Where is the beta globin gene?
The beta globin gene is located on chromosome 11 in humans. It codes for the beta globin protein, which is a subunit of hemoglobin found in red blood cells. Mutations in this gene can lead to conditions such as sickle cell anemia and beta thalassemia.
What is Hb Hope?
Beta thalassemia variant
Can you have both alpha thalassemia and beta thalassemia?
Of coare yes. You can get any hemoglobinopathy from a parent without any connection to other hemoglobinopathy (or any other hereditary disease) from the other parent. Prof. Kornfeld Pal
What does the term thalassemia minor refer to?
If untreated, beta thalassemia major can lead to severe lethargy, paleness, and delays in growth and development. The body attempts to compensate by producing more blood, which is made inside the bones in the marrow.
