Yes, the cAMP pathway involves signaling through cyclic AMP to activate protein kinases, which in turn can lead to the activation of enzymes by phosphorylation. Additionally, cAMP can also bind to transcription factors to regulate gene expression by turning on specific genes.
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When glucose levels are low, the hormone glucagon is released, which activates adenylate cyclase through its receptor. This leads to an increase in cyclic AMP (cAMP) production from ATP. High cAMP levels then activate protein kinase A (PKA), which promotes gluconeogenesis and glycogen breakdown to increase glucose availability. Thus, elevated cAMP serves as a signaling mechanism to mobilize energy reserves when glucose is scarce.
CREB is a transcription factor whose name is short for cAMP response element-binding protein. It is classically activated by the cAMP intracellular signaling cascade, in which elevated intracellular cAMP levels activate cAMP-dependent protein kinase (PKA). PKA then activates CREB by phosphorylating it on specific serine and threonine admino acid residues, changing the properties of CREB so that it can bind DNA and other proteins to regulate transcription of certain genes.
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