Personally I'd probably use the I-80 route.
Take I-95 SOUTH to Washington, D.C.
The best route for driving from Indianapolis to Washington DC is to take Interstate 70 East to Interstate 270 South, then merge onto Interstate 495 East which will take you directly into Washington DC. This route is approximately 600 miles and takes about 9-10 hours depending on traffic and weather conditions.
Interstate 80 connects the two. If you drive across the George Washington Bridge, you won't have to make any turns.
route 66
E842 is the best route across. SS16 to A14 connects to that.
The best route to drive from Chicago to Pittsburgh is to take Interstate 90 East to Interstate 80 East. This route is the most direct and efficient way to reach Pittsburgh from Chicago by car.
Yellowstone National Park has five park entrances, three in Montana and two in Wyoming, however, most of Yellowstone National Park and the "sites to see" are located in Wyoming. To enter Yellowstone National Park at the south entrance (in Wyoming), you travel through the Grand Teton National Park and the John D. Rockefeller Memorial Parkway, which makes it the best route to enter Yellowstone National Park.
a popular cattle drive route in the years after the Civil War
The quickest and shortest route is I-5 North.
The best route for a drive from Salt Lake City to Denver is typically via Interstate 80 East and Interstate 25 South. This route is the most direct and commonly used for traveling between the two cities.
The best route for a drive from Salt Lake City to Phoenix is to take Interstate 15 South. This route is the most direct and efficient, taking you through scenic areas and major cities along the way. It is approximately a 10-hour drive covering a distance of about 650 miles.
The best route to drive from Phoenix to Salt Lake City is to take Interstate 17 North to Interstate 40 East, then merge onto Interstate 15 North. This route is approximately 700 miles and takes about 10-11 hours to drive, depending on traffic and weather conditions.