The best route for driving from Indianapolis to Washington DC is to take Interstate 70 East to Interstate 270 South, then merge onto Interstate 495 East which will take you directly into Washington DC. This route is approximately 600 miles and takes about 9-10 hours depending on traffic and weather conditions.
Personally I'd probably use the I-80 route.
Take I-95 SOUTH to Washington, D.C.
Fly
Interstate 80 connects the two. If you drive across the George Washington Bridge, you won't have to make any turns.
route 66
E842 is the best route across. SS16 to A14 connects to that.
The best driving route from Memphis to Indianapolis typically involves taking I-40 East to I-55 North, then merging onto I-70 East toward Indianapolis. This route covers approximately 380 miles and usually takes around 5.5 to 6 hours, depending on traffic and road conditions. Make sure to check for any construction or traffic updates before your trip for a smoother journey.
The best route to drive from Chicago to Pittsburgh is to take Interstate 90 East to Interstate 80 East. This route is the most direct and efficient way to reach Pittsburgh from Chicago by car.
a popular cattle drive route in the years after the Civil War
The quickest and shortest route is I-5 North.
I-71 South to Columbus, then I-70 West through Indianapolis and on to St. Louis.
The best route for a drive from Salt Lake City to Denver is typically via Interstate 80 East and Interstate 25 South. This route is the most direct and commonly used for traveling between the two cities.