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The top ten cities by population in what the U.S. Census Bureau defines as the Midwest Region of the U.S., based on their July 2011 estimates, are...

  1. Chicago, Illinois (2,707,120)
  2. Indianapolis, Indiana (827,609)
  3. Columbus, Ohio (797,434)
  4. Detroit, Michigan (706,585)
  5. Milwaukee, Wisconsin (597,867)
  6. Kansas City, Missouri (463,202)
  7. Omaha, Nebraska (415,068)
  8. Cleveland, Ohio (393,806)
  9. Minneapolis, Minnesota (387,753)
  10. Wichita, Kansas (384,445)
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