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During the 1400s and 1500s, several European explorers sailed to America, notably Christopher Columbus, who made his first voyage in 1492 under the Spanish flag, intending to find a westward route to Asia. John Cabot, an Italian explorer sailing for England, reached the North American coast in 1497. Other significant figures include Amerigo Vespucci, who explored the South American coast and whose name would later be used for the continent, and Hernán Cortés, who led the expedition that caused the fall of the Aztec Empire in the early 16th century. These explorations initiated widespread European interest and colonization in the Americas.

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