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During the Middle Ages, the Italian city-states, particularly Venice and Genoa, dominated most of the trade routes to the East. They played a crucial role in facilitating trade between Europe and Asia, especially for goods like spices, silk, and precious metals. Their strategic locations and strong naval power allowed them to control maritime trade routes in the Mediterranean and beyond. This dominance lasted until the rise of other European powers and the discovery of new trade routes in the Age of Exploration.

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