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The effects of colonization of Central and South America by Europeans had, in the end, mostly damaging effects on the cultures of those areas. Though there are historical accounts of fellowship and trade between the native cultures of Mexico and the European colonists, in the end most of their relationships soured and ended in tragedy. For example, there have been many historical accounts of Europeans spreading diseases to native cultures that wiped out great numbers of them. In addition to this, a great number of Mexican natives were wiped out by the Europeans when their relationships broke down into outright warfare. A native culture which had weaponry such as spears, axes and clubs usually suffered huge losses when faced with a European force equipped with horses, armor and firearms. In the end, much of the thriving culture present when the Europeans landed was erased or hugely damaged by colonization.

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