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The Santa Fe and Old Spanish Trails primarily served as trade routes, facilitating commerce between the United States and Mexico, while other major trails, such as the Oregon and California Trails, were primarily used for westward migration by settlers. The Santa Fe Trail connected Missouri to Santa Fe, New Mexico, focusing on the exchange of goods, whereas the Old Spanish Trail linked New Mexico with California, also emphasizing trade and cultural exchange. In contrast, trails like the Oregon Trail were heavily traveled by pioneers seeking land and opportunities in the West. Thus, the main difference lies in their purposes: commercial trade versus migration.

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