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Problems that the colonies faced were relatively large. They suffered from poor sanitation in their cities that caused health problems. Sometimes, Indian attacks, too. They also suffered from poor housing and malnutrition. In the later times, colonies suffered from British taxation and other things.
They faced the world ;)
D-Day was a decisive invasion that turned the tide in WWII. Without success in this battle by the Allies, the face of world government would have surely been much different.
Only a small few found success farming and ranching on the plains as it was very difficult. The poor weather was one of the most significant problems they face.
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In their epic journey into unexplored America in the first decade of the 19th century, Lewis and Clark faced many serious obstacles to success. Foremost among these were the threat from hostile Native tribes, the severity of winter and summer weather in the wilds, the possibility of injury or illness far from adequate medical care, and of course the simple fact of "the unknown": they did not know how far they would need to travel, nor even if they stood any real chance of success at finding a viable passage to the Pacific Ocean.