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Doxorubicin is fatal to a cell primarily because it intercalates into DNA, disrupting the normal function of the genetic material and inhibiting DNA replication and transcription. This leads to the formation of free radicals that cause oxidative damage to cellular components, including membranes and proteins. Additionally, doxorubicin can trigger apoptosis, or programmed cell death, as a response to the extensive DNA damage and cellular stress it induces. These mechanisms collectively contribute to its effectiveness as a chemotherapeutic agent but also underscore its cytotoxic nature.
What else can I help you with?
Is doxorubicin is water soluble?
Doxorubicin has a solubility of 10mg in 1 ml of water, which should be warmed slightly.
What drug combinations are commonly used in treatment of small cell lung cancer?
cyclophosphamide (Cytoxan), doxorubicin (Adriamycin), and vincristine (Oncovin), or etoposide and cisplatin.
What is the dosage form of doxorubicin?
Intravenous
What is the antidote for Doxorubicin?
hyaluronidase
What are antitumor antibiotics?
Antitumor antibiotics are made from natural substances such as fungi in the soil. They interfere with important cell functions, including production of DNA and cell proteins. Doxorubicin and bleomycin belong to this group of chemotherapy drugs.
What has the author Jamei R Eng written?
Jamei R. Eng has written: 'Pharmacogenomics of paclitaxel and doxorubicin resistance in human MCF-7 breast cancer cell lines'
How does doxorubicin kill cells?
Doxorubicin kills cells primarily by intercalating into DNA, which disrupts the double helix structure and inhibits DNA replication and transcription. It also generates reactive oxygen species (ROS) that cause oxidative damage to cellular components. Additionally, doxorubicin can interfere with topoisomerase II, an enzyme crucial for DNA unwinding during replication, leading to double-strand breaks. Collectively, these mechanisms result in cell cycle arrest and apoptosis, particularly in rapidly dividing cancer cells.
How does doxorubicin affect DNA methylation?
Doxorubicin can induce changes in DNA methylation patterns by affecting the activity of DNA methyltransferase enzymes. It can lead to global hypomethylation or hypermethylation of specific gene promoters, influencing gene expression and potentially contributing to its cytotoxic effects.
With doxorubicin admistration it is essential that the nurse closely monitor for the patients?
yes
Drugs containing primary amine as afunctional group?
Doxorubicin, an anticancer drug.
Fatal dermatology diseases?
squamos cell carcinoma please explain
What is the most fatal type of lung cancer?
small cell cancer
