Probably, almost certainly, the .600 Nitro Express is the overall most power handgun bullet.
Let me alter this answer by saying the .600 Nitro Express is a rifle round that one company made a pistol for. The most powerful handgun cartridge is the 500 S&W Magnum.
In most circumstances, no. The bullet is too large to chamber in the handgun.
No
Unknown
Demons are immortal - its just part of the definition.
ANY firearm that discharges a bullet is capable of causing a lethal injury. 500 smith and Wesson. Is a very lethal handgun.
A VERY good handgun- for most puposes. Durable, reliable, accurate, and powerful.
The magnum .55 is the most powerful, but some Desert Eagle has the highest calibre bullet.
Pistol.
No, it cannot.
No, you cannot.
Not even close. There are several more powerful handgun cartridges, not counting the single shot pistols that use rifle cartridges. While Dirty Harry may have proclaimed it to be "The most powerful handgun in the world"- it is not.
The grooves in the barrel.