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Prothrombin and factor VII are both essential proteins involved in the blood coagulation process. Prothrombin, also known as factor II, is a vitamin K-dependent plasma protein that is converted into thrombin during the clotting cascade, playing a critical role in the formation of fibrin clots. Factor VII, another vitamin K-dependent coagulation factor, activates factor X in the presence of tissue factor, initiating the extrinsic pathway of coagulation. Both factors are crucial for maintaining hemostasis and preventing excessive bleeding.
What else can I help you with?
How many executions did Henry vii do?
7
Who was king of France in 1163 till 1345?
Louis VII
Why did Edward VII die at the age of 15?
Its Edward VI, not Edward VII. Edward VI (12th October 1537 - 6th July 1553) aged 15. He died from tuberculosis.
How long ago was Henry vii alive?
King Henry VII died on the 21st April 1509 (aged 52) at Richmond Palace, England. Therefore: 2015 minus 1509 = 506 years ago.
When did the edwardians live?
During the reign of Edward VII, 1901-1910.
What coagulation factors are measured by the PT?
Prothrombin time (PT) measures the activity of coagulation factors in the tissue factor pathway of the coagulation cascade.
What substances activate the release of prothrombin?
Prothrombin release is primarily activated by the presence of certain substances that promote the coagulation cascade, notably tissue factor (thromboplastin) and calcium ions (Ca²⁺). Tissue factor is exposed at the site of vascular injury and interacts with factor VII, leading to the activation of factor X, which ultimately converts prothrombin to thrombin. Additionally, phospholipids from activated platelets also play a crucial role in this process.
What are the 13 clotting factors?
factor I (fibrinogen), factor II (prothrombin), factor III (tissue thromboplastin), factor IV (calcium), factor V (proaccelerin), factor VI (no longer considered active in hemostasis), factor VII (factor-vii), factor VIII (antihemophilicfactor), factor IX (plasma thromboplastincomponent; Christmas factor), factor X (stuart-factor-stuart-prower-factor), factor XI (plasma thromboplastinantecedent), factor XII (factor-xii), factor XIII (fibrin stabilizing factor).
What is the clotting factor that is activated just before a thrombus is formed?
prothrombin
Why do jaundiced patients have prolonged prothrombin time?
the liver synthesizes all the clotting factors, and requires vitamin K to activate factors II, VII, IX and X. Reduced plasma concentration of coagulation factors occurs in liver damage, which is easily recognized by prolongation of prothrombin time, which depends on factors I, II, V, VII and X.
What is prothrombin activator?
Prothrombin activator is a complex that initiates the clotting cascade by converting prothrombin, a plasma protein, into thrombin. This process is crucial for blood coagulation, as thrombin subsequently transforms fibrinogen into fibrin, leading to the formation of a stable blood clot. Prothrombin activator is primarily composed of factor Xa and factor Va in the presence of calcium ions. Its activity is essential for hemostasis, preventing excessive bleeding during injury.
What are the phases of coagulation?
These are the three phases:Phase 1: Formation of prothrombin activatorThe prothrombin activator is formed through intrinsic and/or extrinsic pathway. Usually it is formed by both. Its formation is triggered by tissue-damaging events and it involves a series of procoagulants. Each pathway cascades towards Factor X (i.e. the Stuart Factor) that complexes with Ca2+, platelet factor 3 (PF3), and Factor V to form the prothrombin activator.The intrinsic pathway is triggered by negatively charged surfaces of activated platelets, collagen, and glass and it uses factors present within the blood. As for the extrinsic pathway, it is triggered by exposure to tissue factor (Factor III). The extrinsic pathway bypasses several steps of the intrinsic pathway so it is faster. Once the prothrombin activator is formed, the clot forms in 10-15 seconds.Phase 2: Prothrombin's conversion to thrombinThe prothrombin activator catalyses the transformation of prothrombin to thrombin.Phase 3: Fibrinogen conversion to fibrinThrombin (Factor II) converts soluble fibrinogen to the solid fibrin. The fibrin formed will cause the plasma to become a gel-like trap for formed elements, forming the structural basis of the clot. The thrombin along with Ca2+ activates Factor XIII to cross-link fibrin. This will strengthen and stabilise the clot.
What are the 12 factors of blood clot?
http://web.indstate.edu/thcme/mwking/blood-coagulation.html Factor I = Fibrinogen Factor II = Prothrombin Factor III = Tissue factor Factor IV = Calcium Factor V = Labile factor Factor VI - Does not exist as it was named initially but later on discovered not to play a part in blood coagulation. Factor VII = Stable factor Factor VIII = Antihemophilic factor A Factor IX = Antihemophilic factor B or Christmas factor (named after the first patient in whom the factor deficiency was documented) Factor X = Stuart Prower factor Factor XI = Antihemophilic factor C Factor XII = Hageman factor Factor XIII = Fibrin stabilising factor
What is thromboplastin?
substance in blood and tissues which, in the presence of ionized calcium, aids in the conversion of prothrombin to thrombin. Extrinsic and intrinsic thromboplastin are formed as the result of the interaction of different clotting factors; the factors that combine to form extrinsic thromboplastin are not all derived from intravascular sources, whereas those that form intrinsic thromboplastin are.activated partial t. time - see http://www.answers.com/topic/activated-4 partial thromboplastin time.extrinsic t. - the prothrombin activator formed as a result of interaction of coagulation factors III, VII, and X which, with factor IV, aids in the formation of thrombin.t. generation time (TGT) - evaluates the first stage in blood coagulation by measuring the efficiency of prothrombinase formation.intrinsic t. - the prothrombin activator formed as a result of interaction of coagulation factors V, VII, IX, X, XI and XII and platelet factor 3 (PF-3), which, with factor IV, aids in the conversion of prothrombin to thrombin.plasma t. antecedent (PTA) - http://www.answers.com/topic/clotting-1 factor XI; deficiency occurs in cattle and dogs, causing mild to severe bleeding tendencies called hemophilia C.plasma t. component (PTC) - http://www.answers.com/topic/clotting-1 factor IX; deficiency causes http://www.answers.com/topic/haemophilia-b. Called also Christmas factor, antihemophilic factor B, autoprothrombin II.t. time - see http://www.answers.com/topic/activated-4 partial thromboplastin time.tissue t. - factor III, a material derived from several sources in the body (e.g. brain, lung), and is important in the formation of extrinsic prothrombin converting principle in the extrinsic pathway of blood coagulation. Called also tissue factor.
What are the different clotting factors?
There are 13 clotting factors identified in blood that work together in the coagulation cascade to form blood clots. These factors include Factor I (fibrinogen), Factor II (prothrombin), Factor III (tissue factor), Factor IV (ionized calcium), Factors V, VII, VIII, IX, X, XI, XII, XIII, and von Willebrand Factor.
What is a PT INR?
prothrombin time is a factor involved in the clotting process. the factors nearly all of which are produced in the liver.
What is necessary to convert inactive prothrombin to active thrombin?
To convert inactive prothrombin to active thrombin, it is necessary to cleave prothrombin through the action of the enzyme prothrombinase. This complex, primarily composed of factor Xa and factor Va, operates in the presence of calcium ions and phospholipids. The cleavage results in the formation of active thrombin, which plays a crucial role in the coagulation cascade by converting fibrinogen to fibrin and activating additional coagulation factors.
