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Although I suppose you technically could, it would be very dangerous and unethical.

Yorkshire Terriers, as with many other popular and small dog breeds, have a wide range of inherited disorders present in the breed, and close inbreeding--with a brother-sister mating would most certainly be--would raise the risk of producing one of those problems exponentially. Being very small, they often have difficulty in giving birth, raising your risks even higher.

Dog breeding in general should only be undertaken by those with a set goal in mind for the offspring, who have performed all the necessary health clearances for the breed they are breeding, have researched pedigrees, and are very familiar with the problems present in their breed and their bloodline of the breed. Inbreeding should be performed by a much, much smaller group of even those responsible breeders.

In short--no, you shouldn't breed your dogs to one another. Keep them separate while the girl is in season.

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Q: Can you breed my male and female brother and sister yorkies?
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