On March 26, Harrison became ill with a cold. According to the prevailing medical misconception of that time, microorganisms being then unknown, it was believed that his illness was directly caused by the bad weather. However, it was more than three weeks after the inauguration before Harrison showed the first signs of ill health and modern studies have shown that exposure to adverse weather does not cause respiratory illnesses. It is likely he was a victim of the common cold virus, exacerbated by the drastic pressures of his changed circumstances.
The cold worsened, rapidly turning to pneumonia and pleurisy. He sought to rest in the White House, but could not find a quiet room because of the steady crowd of office seekers; in addition, his extremely busy social schedule made any rest time scarce. Harrison's doctors tried cures, applying opium, caster oil, and Virginia snake weed. However, the treatments only made Harrison worse, and he became delirious. He died nine days after becoming ill, at 12:30 a.m. on April 4, 1841, of right lower lobe pneumonia, jaundice, and overwhelming septicemia; he became the first American president to die in office.
William Harrison Graham died in 1923.
William Harrison Moore died in 1935.
William Harrison Riley died in 1907.
William Harrison Holly died in 1958.
William Graham-Harrison died in 1949.
William Harrison-Broadley died in 1896.
William Harrison Dimmick died in 1861.
Chester William Harrison died in 1994.
William Harrison Folsom died in 1901.
William Harrison Cowlishaw died in 1957.
William Harrison - bishop - died in 1920.
William Henry Harrison Seeley died in 1914.