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How did the Union casualties of the Overland campaign compare to the casualties suffered by previous Union generals in the Eastern Theater?

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Under the command of generals McClellan, Burnside, and Meade, the Army of the Potomac suffered 82,600 casualties in two years of battling the Army of Northern Virginia. Under General Grant's Overland campaign of 1864, Union casualties numbered 64,000 in a span of six weeks.
General John Pope's casualties in the Battle of the Second Bull Run are excluded from these figures as he commanded the Army of Virginia for the most part, with troops from the Army of the Potomac arriving too late to impact the battle.
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