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Hydrocodone & tramadol are both opioid agonist analgesics. They are both micro (morphine) agonists, and (unlike buprenorphine), they are both full agonists, and not partial. Although tramadol's chemical structure is simpler than that of hydrocodone, its pharmacology is more complex. And even though their pharmacologies differ, somewhat, both share key features related to the prototype narcotic, codeine. Both tramadol and hydrocodone share a 3-methyl ether grouping (as does codeine), and all three are demethylated by the liver to corresponding, more active phenols. Although tramadol is arguably a less potent analgesic than hydrocodone, it is difficult to compare and contrast the relative ratio equivalencies between the two, because hydrocodone's absolute potency equivalency has not been established. In other words, unlike many other narcotics, experts do not agree on how potent and efficacious hydrocodone really is. Most believe hydrocodone is less potent than oxycodone, but the extent of the reduced potency here is debatable (the relative differences in potency between the analogous hydromorphone vs oxymorphone (Dilaudid vs Numorphan), is more straight forward. Tramadol has significant SNRI action, while hydrocodone does not. Interestingly, however, both hydrocodone and codeine can cause seizures, but not as readily as tramadol (or pethidine, for that matter). There is some evidence that hydrocodone, along with codeine and oxycodone, might have very mild SNRI effects, just as tramadol does, but much weaker. Tramadol itself is a very weak opioid agonist, and most of the opioid agonist effect derived from the compound is through a hepatic demethylation. However, unmetabolized tramadol has a rewarding effect (dopamine, rat, NAC shell) clearly in greater potency than is accountable by its very weak mU opioid effect. Could it be that unmetabolized (parent) tramadol behaves similarly to the drug MDMA, and that the metabolised M1 is similar to hydrocodone? Now, a portion of the human population can not effectively perform 3 ortho demethylation, and these people probably will derive lesser analgesic benefit from tramadol, codeine, and even hydrocodone and oxycodone, and in this rank ordering of significance. Tramadol is a synthetic analog of codeine. Hydrocodone is a conger of codeine, as is oxycodone. Phenomenologically, it is best to think of tramadol as a weak version of ketobemidone, for those in which the drug is efficacious. Both analgesics raise the seizure threshold, and both are nmda-antagonists. The specific "leg pleasure" both drugs produce, coupled with not wanting to move one's body whatsoever, is a striking similarity. It would appear, perhaps, that not only does tramadol have far greater abuse potential than previously thought, but that, in fact, tramadol may represent one of the most abusable of all opioids, and even greater than heroin.
Wiki User
∙ 13y ago
Wiki User
∙ 12y agono tramadol is great its is a pain blocker, it doesn't make you feel messed up, and no pain nothing I've ever taken has worked like that but it is not a party drug like hydrocodone. i took them at work this week and i am an electrican i need a clear head
Wiki User
∙ 10y agoNo it is not... Hydrocodone is the active opiate (codeine) derived ingredient in Vicoden (Vicoden would be a mix of a low dose of hydrocodone and Acetometaphan). Tramadol is something completely different... A painkiller but one that is not derived from opiates.
Wiki User
∙ 14y agoShort answer:
tramadol is a synthetic opiate, while hydrocodone is a semi-synthetic developed from two naturally occurring opiates (codeine and thebaine). Both work on opiate receptors in the brain.
Wiki User
∙ 15y agoTramadol is usually marketed as the hydrochloride salt (tramadol hydrochloride) which gives it the name Tramadol HCL. Tramadol's chemical structure is quite different from those of opiates like HYDROCODONE. They are both used to treat moderate to moderately severe pain but are chemically totally different. Some people say that tramadol's effects are very close to synthetic morphine.
Wiki User
∙ 15y agoThey are both opioid analgesics, very similar in property, and both often mixed with APAP (acetaminophen) to form Percocet, Norco/Lortab/Vicodin, etc. Oxycodone is, however, the stronger of the two.
Wiki User
∙ 14y agoOxycodone/oxycontin is a much stronger opiate. It is known to produce a high similar to that of heroin. Hydrocodone feels really good too, but it doesn't even come close to producing the feeling of absolute, utter euphoria that heroin does.
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What does the hlc stand for after tramadol?
The HCL in Tramadol HCL stands for hydrochloride. Tramadol is sold as Tramadol and Tramadol HCL
Is ultram like a Vicodin?
No. Ultram is tramadol HCL. It is a completely different drug that hydrocodone (Vicodin) with a different therapeutic action. Standard dose for standard dose, hydrocodone is somewhat more powerful than tramadol.
Can you take tramadol hcl 50 mg amd ambien 10mg?
Tramadol isn't a narcotic. You can become addicted to hydrocodone. Not tramadol so much.
Is sulfur in tramadol hcl?
does tramadol hcl have sulfur in it
What is the difference between Tramadol and Tramadol HCI?
You can find HCl suffix after many medicine contents. The difference is Tramadol HCl has a better bio availability than Tramadol, that means more portion of the medicine may be absorbed through the intestine. EXPLANATION: The stomach has an acidic environment. Tramadol HCl is a weak acid, so it will less ionize in acidic environment and only unionized molecules are absorbed through the gut. So Tramadol HCl is better at being absorbed through the gut than Tramadol.
Does Tramadol HCl cause sleepiness?
Yes, it does.
Is trimadol a narcotic?
no. the medication Ultram (tramadol hcl) is non-narcotic; even though they have the same effect as hydrocodone if taken in high doses.
Is tramadol hcl addictive?
Not to me, i have taken for a couple of years
Does Tramadol HCL contains cocaine?
Pure tramadol HCl does not contain contain cocaine, as tramadol and cocaine are two different substances. However, it is possible that something sold on the street might contain a mixture of these two chemicals.
Why do they give you Tramadol HCL 50mg what is it used for?
Tramadol HCL is a mild pain blocker that cuts the pain signal in the brain. It is used to releaive mild to moderate pain.
Is 50mg of tramadol the same as 50mg of tramadol hcl?
Tramadol: the whole pill works within an hour. Tramadol HCL: extended release and will work all day long. You can just chew the Tramadol pill and it will get the same effect, i always chew all my eight or ten 200mg tramadol pills
Is human tramadol hcl the same as your dogs tramadol?
Yes, it's the same but have a different dosage for people and dogs.
