Sounds very much like bearing. If you jack it up and while holding wheel at 12 and 6 o'clock , try moving . On mine I had felt slight play and I was able to have it replaced under the drive line warranty .
Brake or bearing problem is my guess. Start by looking for a stuck caliper as this is a common problem. If the vehicle is used for pulling a boat and is backed into the water regularly then more than likely a bearing problem.
There can be several reasons , broken bearing, broken self adjuster, sheared break pad.
Get a manual for this vehicle.
The sound coming from a wheel could be a brake or wheel bearing problem. Check both as letting the issue continue could damage the vehicle.
If it is a rear wheel drive vehicle it is either low oil in the rear end or an axle bearing. On a front wheel drive vehicle it is probably a bearing.
Bad tire? Bent rim? Bad wheel bearing? Try moving tire to another location on the vehicle and see if problem moves with tire
Vehicle type and year is essential for proper answer.
The most common cause of the rumbling noise underneath your vehicle is a bad wheel bearing or CV joint. You should not drive the vehicle until the problem is properly diagnose.
Bob
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Yes, a wheel bearing can make a tire fall off while it is being driven. If the bearing does fall off, the tire can then fall off the vehicle.
there is no problem....great vehicle!