Systemic in medicine refers to something that affects the entire body or a system within the body. A disease or toxin could affect the entire body or maybe just the immune, cardiovascular, or any other of the ten human systems.
Systemic means relating to or spread throughout and affecting a group, system, or body as a whole.
A systemic drug means when a drug taken and it reaches to Blood is called systemic circulation. there are many ways for systemic drug administration like Oral, I.V, I.M, S.C
Bioavailability in pharmacology refers to the fraction of a drug that reaches the systemic circulation and is available to produce an effect after administration. It is typically expressed as a percentage and takes into account how much of the administered dose is absorbed and becomes available to the body. Factors like drug formulation, route of administration, and first-pass metabolism can affect a drug's bioavailability.
Bioavailability is used to describe the fraction of an administered dose of unchanged drug that reaches the systemic circulation, so we need chemically stable drug in order to increase the chance of drug absorbance and thus increased bioavailability.
They are available in tablet, capsule, liquid, and injectable forms.
Insulin should be administered!!
Glucocorticoids can make a person susceptible to infection when they are administered for too long as a drug.
Needle oral and smking
local action
Basically no, due to two reasons:First, the drug is incompletely absorbed from the gastrointestinal tract, some of it exits the body unabsorbed along with the feces.Second, the absorbed amount of the drug undergoes first-pass metabolism; where the drug enters the hepatic portal system and is partly metabolized by the liver, thus, the amounts of drug reaching the systemic circulation unchanged is even less.Therefore, the bioavailability of orally administered drugs is always below a 100% and can never be a 100%.Moreover, its not logical for it to be more than 100%, since bioavailability by definition is the fraction of the amount of the drug administered that reaches the systemic circulation unchanged. It can't be more than 100% unless larger amounts of the drug reaches your circulation than the amount you already took orally, which is impossible.While it cannot be more than 100% for a single dose, if the drug is administered more often than the period necessary for complete elimination from the body, total serum concentration may be higher than 100% of the single dose. Such is the case with most antibiotics for example, which are administered at intervals of 4-6-12 hours to achieve and maintain plasma concentrations higher than the single dose. (PS I am not a health professional)
Systemic means that the drug acts in the whole body(usually drugs that are administered orally or i.v),having effect i various parts of the body(e.g:aspirin lowers fever AND thins blood AND eleviates pain AND can induce bleeding in the gastric tract).LOCAL means that the drug only acts in the area where it is administred(e.g:strepsils for a throatache,aciclovir oilment for herpes,etc) and is not absorbed into the bloodflow,therefor does not act in multiple levels of the body.
Yes. It is very common to get the systemic effects of locally acting drug. Specially the allergic reactions.
amphotericin b
Caverject is indeed a drug. It is used to treat erectile dysfunction. It's administered by injection into the penis.