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The diseases and slavery that the European involvement in Central America, mostly headed by Cortes, had a huge impact on the United States, though indirectly.
Due to Cortes'/European involvement this happened:
25 Million Native-American-Indians died from diseases and other reasons.
Because of local (Spanish, not native American) protest (banned the use of native Americans as slaves), the Atlantic Slave Trade was indirectly started, the Africans believed to be tougher then the native Americans, and were able to 'take' more.
You get the idea, we're talking late 1500s, so there wouldn't have been much actual (what we consider today) America yet. Those two things are the most prominent of the influences that Cortes had on the US history, however there is sure to be much more.
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