There is no area code +1 421 in North America (USA, Canada, etc.)
+421 is the telephone country code for Slovakia, used for international calls.
(The plus sign means "insert your international access prefix here." From a GSM mobile phone, you can enter the number in full international format, starting with the plus sign. The most common prefix is 00, but North America (USA, Canada, etc.) uses 011, Japan uses 010, Australia uses 0011, and many other countries use different prefixes.)
There is no area code for (421) within the United States. What you are looking at is an international calling code for Slovakia. Slovakia is located along the border of the Czech Republic near Russia.
The area code 0121 is in Birmingham.
The country code and area code of Hnusta, Slovakia is 421, (0)47.
The country code and area code of Yefren, Libya is 218, (0)421.
The country code and area code of Bardejov, Slovakia is 421, (0)54.
The country code and area code of Bratislava, Slovakia is 421, (0)2.
The country code and area code of Gelnica, Slovakia is 421, (0)53.
The country code and area code of Hlohovec, Slovakia is 421, (0)33.
The country code and area code of Holic, Slovakia is 421, (0)34.
The country code and area code of Humenne, Slovakia is 421, (0)57.
The country code and area code of Hurbanovo, Slovakia is 421, (0)35.
The country code and area code of Kezmarok, Slovakia is 421, (0)52.
The country code and area code of Levice, Slovakia is 421, (0)36.