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The middle east, Ancient India and Ancient Greece in about the 12th century BC. It was the 8th BC in central Europe and 6 th BC in Northern Europe. Since it was so long ago no one can say who actually found the first iron ore. new study led by Children's Hospital Oakland Research Institute senior scientist, Elizabeth Theil, Ph.D., is the first to suggest that a small protein or heptapeptide (seven amino acids wrapped into one unit) could be used to accelerate the removal of iron from ferritin. The results of this study may help scientists develop new medications that dramatically improve the removal of excess iron in patients diagnosed with blood diseases such as B-Thalassemia (Cooley's anemia) or Sickle Cell Disease.
The study appears in this month's issue of the Journal of Biological Chemistry and was conducted by Dr. Theil and her co-authors Xiaofeng S. Liu, postdoctoral fellow at Children's Hospital Oakland Research Institute, Marvin J. Miller, Ph.D. and Leslie D. Patterson, a predoctoral student, both from the University of Notre Dame. The scientists knew that the ferritin protein cage had pores that could open and close. It was also known that chelators (a method to detoxify blood) removed iron faster when the pores were open.
"We wanted to prove a hypothesis that a small protein or peptide could bind to ferritin and could be used to regulate ferritin pores," said Dr. Theil. "Our hypothesis was correct. We proved that when a binding peptide of seven amino acids, a heptapeptide, is coupled with Desferal the rate of removal of iron from ferritin is eight times faster." Desferal is currently used to detoxify the blood of patients with iron overload and is a common therapeutic remedy.
Ferritin is a protein that concentrates iron in its inner core or 'cage'. It plays a critical role in understanding iron overload, which can lead to a variety of symptoms including chronic fatigue, weakness, joint pain and arthritis. If left untreated, iron overload can lead to serious problems, including diabetes, liver and heart disease.
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Article adapted by Medical News Today from original press release.
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The study's results are based on laboratory tests. The National Institutes of Health (NIH), the Cooley's Anemia Foundation and Children's Hospital & Research Center Oakland provided funding for this research.
Click here for more information on Dr. Theil's research.
Research at Children's Hospital & Research Center Oakland, CA
Research efforts at Children's Hospital & Research Center Oakland are coordinated through Children's Hospital Oakland Research Institute (CHORI). Children's Hospital Oakland is Northern California's only freestanding and independent children's hospital. CHORI's internationally renowned biomedical research facility brings together seven centers of excellence that are devoted to clinical and basic science research to treat and prevent disease. CHORI has approximately 300 staff members and an annual budget of more than $49 million. The National Institutes of Health is CHORI's primary funding source. The institute is a leader in translational research, bringing bench discoveries to bedside applications. These include providing cures for blood diseases, developing new vaccines for Infectious Diseases and discovering new treatment protocols for previously fatal or debilitating conditions such as cancers, sickle cell disease and thalassemia, diabetes, asthma, HIV/AIDS, pediatric obesity, nutritional deficiencies, birth defects, hemophilia and cystic fibrosis.
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What was discovered in the Iron age?
In the Iron Age, people discovered how to extract iron from ore and use it to make tools, weapons, and other objects. This advancement revolutionized technology and allowed for the development of more sophisticated societies and industries.
How was cast iron discovered?
Cast iron was discovered by accident during the Iron Age when iron ore was mixed with charcoal in a hot fire, resulting in the production of molten iron which could be cast into different shapes. This process was refined by various civilizations over time, leading to the widespread use of cast iron in tools and cookware.
Where was iron discovered?
Iron was discovered and used by ancient civilizations in the Middle East around 3000 BC. It was likely discovered as a byproduct of copper smelting, and its wide availability and usefulness allowed it to revolutionize technology and society.
How did the Celts discover iron?
The Celts likely discovered iron through contact with earlier civilizations that were already using iron. They may have observed iron ore deposits or seen iron objects made by other groups, sparking their own experimentation and adoption of ironworking techniques.
What colony founded iron ore?
The colony of Jamestown in Virginia is known for founding iron ore deposits in America. Iron ore was discovered in Jamestown in the early 17th century, and its mining and processing played a crucial role in the colony's economy and development.
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Iron was discovered long before we had people who could be called scientists.
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