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Which type of mutation would have a greater effect on the sequence of amino acids in a protein a base-pair substitution or a frame shift mutation?
Wiki User
∙ 13y ago
Point mutations are normally single base substitutions in a DNA strand. For example:
Imagine this is a DNA strand split up into 3 bases.
Instead of: The fat cat ate the wee rat and hat
You will get: The fat bat ate the wee rat and hat
There is not much of a change. It may result in a different amino acid being placed there when it is translated.
Frameshift mutations on the other hand are much more devastating.
Instead of: The fat cat ate the wee rat and hat
You will get: The fat bca tat eth ewe era tan dha t
You can see that the addition (or even deletion) of one base changes EVERYTHING after it. Therefore, most of the amino acids will be different than the ones intended when it is translated.
Therefore, frameshift mutations have the large effect.
Wiki User
∙ 14y ago
Wiki User
∙ 10y agoBoth types of mutation have the potential to cause a large effect.
In general, a frameshift mutation is more likely to cause a large effect. This is because it shifts the 'reading frame' - so that all of the subsequent codons (groupings of 3 bases that are read to determine which amino acid will be added) will be changed.
A point mutation is when a single base is replaced. This can either result in the same amino acid being added to the protein being synthesised (a silent mutation), a different amino acid being added (a missense mutation) or in a STOP codon (a nonsense mutation).
If a point mutation causes a premature STOP codon - this is quite likely to have a large effect on the protein.
Wiki User
∙ 13y agoFrame shift mutation
Anonymous
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Why would an insertion or deletion mutation have more effect than a substitution mutation?
Base-pair insertions have a greater effect because they shift the information on the DNA down and change all following information, whereas substitutions may change only one amino acid or have no effect. -The base-pairs code for amino acids in groups of three. If just one base is added in, then this grouping is shifted upstream by one. The incorrect amino acids will be coded for and added to the protein being built. It could possibly stop the protein from being synthesized fully if the change creates a stop codon. This usually hinders the protein from functioning. -Base-pair substitution mutations only affect the codon (set of 3 base pairs) that it actually occurs in. If the mutation is in the first base-pair of the codon then the amino acid will change. If the mutation is in the second or third position of the codon then amino acid may or may not change; this is because amino acids can be coded for by more than one codon, but the first base-pair (and sometimes the second) is usually the same. A substitution can also change a codon to a stop codon. This may keep the amino acid the same, change only one amino acid (which does not always stop the protein from working), or cause the protein to prematurely stop being built.
How might a point mutation in a gene affect the reasulting protein?
point mutations include substitutions insertions and deletions of a single nuceotide in DNA. CONSIDER: insertions and deletions have a greater effect on proteins that do substiutions because insertions and deletions affect every amino acid that is specified by the nucleotides that follow the point of mutation CONSIDER: a substitution affects a single amino acid a change in more than one amino acid is more likely to alter the ability of the protein to function narmally than is a change in a single amino acid CONSIDER: follow me on twitter @Rocco_Gone_Ham
Which kind of mutation has the greater potential to affect the evolution of a population a mutation to a body cell or a mutation in an egg cell?
Mutations that occur during gametogenesis (formation of egg and sperm) are called germ-line mutations. They are more significant than somatic mutations (which occur in body cells) because they can be transmitted to the next generation whereas somatic mutations are not transmitted to the next generation.
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A frame-shift mutation has greater potential to affect the evolution of a population because it can alter the entire reading frame of a gene, leading to a non-functional protein. This can result in significant changes to an organism's phenotype, potentially affecting its survival and reproduction, and thereby influencing the population's evolution.
Why frameshift mutations have greater effect than point mutations?
A substitution mutation means that one base was copied incorrectly within a string of DNA. Since it takes three DNA bases to code for a single amino acid, only one amino acid is affected. A frameshift mutation, on the other hand, refers to an insertion or deletion of any number of DNA bases NOT divisible by three. This mutation throws off EVERY other amino acid after it and tends to be devastating. For example, if you had this sequence: actgactga, you would get three amino acids: act, gac, and tga. If you had a substitution error, it might yield cctgactga. In this case, only the first acid would be different. In the case of an insertion (one type of frameshift mutation), you might get: acttgactga. As you can see, a t-base has been added towards the beginning. in this case, you would get the amino acid sequence: act, tga, ctg. EVERY amino acid following the mutation is different from what it should be.
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