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As the action potential passes an area on the axon, sodium channels are closed, preventing influx of more sodium ions. At the same time, voltage-sensitive potassium channels open, allowing the membrane potential to fall quickly. After this repolarization phase, membrane permeability to potassium remains high, allowing for the "afterhyperpolarization" phase.

During this entire period, while the sodium ion channels are forced closed, another action potential cannot be generated except by a much larger input signal.

This helps to prevent the action potential from moving backwards along the axon.

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Q: Why does regeneration of the action potential occur in one direction?
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