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If it impairs your operation of the vehicle in any way (e.g.: makes you drowsy - slows your reaction time - makes you hallucinate - etc) - yes, most definitely. Even non-presecription drugs fall into this category. You could be charged with DUI (Driving Under the Influence).

If you are the holder of a CDL - you have even more restrictions placed on you.

Technically, it's not taking the drugs that's illegal; it's operating a car while in an impaired condition that's illegal. If the drugs do not impair you, then it's legal; if they do, then it isn't.

This below link to an article on prescription drugs and driving may help:

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Q: Are prescription drugs illegal to take when driving?
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