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Are there any risks for birth defects if the father takes depakote?
Wiki User
∙ 10y ago
Sperm abnormalities are documented with Depakote. Some Anti-Epileptic Drugs (AEDs) are associated with sperm abnormalities, including low semen volume, low sperm count and abnormal sperm motility. The following AEDs have been linked to sperm abnormalities: carbamazepine, oxcarbazepine and valproate (Depakote). I am not aware of congenital malformations caused by a Father utilizing Depakote.
When taken by the Mother, Valproate can cause major congenital malformations, particularly neural tube defects (e.g., spina bifida). Depakote can cause decreased IQ scores following in utero exposure. As a general rule, Depakote is contraindicated in pregnant women unless benefit exceeds risk considering alternative treatment failures.
Dr. B., Clinical Pharmacist
Wiki User
∙ 10y ago
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