No , not according to the 2007 Ford Expedition Owner Guide :
( use " regular " unleaded gasoline , 87 octane )
* blended with up to 10 % ethanol is O.K. but it is not designed to use E85
The 2010 Ford Expedition runs on flex-fuel (FFV).
The 2011 Ford Expedition runs on flex-fuel (FFV).
The 2009 Ford Expedition runs on flex-fuel (FFV).
The 2012 Ford Expedition runs on flex-fuel (unleaded/E85).
The 2013 Ford Expedition runs on flex-fuel (unleaded/E85).
The 2014 Ford Expedition runs on flex-fuel (unleaded/E85).
The 2007 Ford Expedition runs on regular unleaded.
The electric fuel pump is INSIDE the fuel tank
The 2009 Ford Flex runs on regular unleaded.
The 2014 Ford Flex runs on regular unleaded.
The 2010 Ford Flex runs on regular unleaded.
The 2011 Ford Flex runs on regular unleaded.