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Yes, you can. I have been taking Depakote and Lithium for the past three months, along with Decipramine and Seroquel. I started with 200mg of Seroquel per day and I'm now down to 50mg per day. No problems here. BUT please find a qualified doctor to answer this for your specific case. this isn't aspirin and soda that we're mixing, and each person is different. The key is to make sure your doctor knows your medical history so that you are not a high risk patient for either drug, that you know the potential side effects for each drug well and that you call your doctor if something goes wrong.

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Torey Greenfelder

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15y ago

Yes, you can. I have been taking Depakote and Lithium for the past three months, along with Decipramine and Seroquel. I started with 200mg of Seroquel per day and I'm now down to 50mg per day. No problems here. BUT please find a qualified doctor to answer this for your specific case. this isn't aspirin and soda that we're mixing, and each person is different. The key is to make sure your doctor knows your medical history so that you are not a high risk patient for either drug, that you know the potential side effects for each drug well and that you call your doctor if something goes wrong.

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Q: Can seroquel and depakote be taken together without risk?
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Can Prozac and depakote be taken together?

I don't recommend it, I did so, and experienced self-induced seizures. You can take Depakote with Tramadol as long as you don't exceed more than 3 a day. I am on both meds and the pharamists told me that and I have lived by it, and I have not had seizures but then again I am taking Depakote for BiPolar Disorder not epilepsy.


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Yes, ibuprofen can be taken in conjunction with Depakote as long as it is an over the counter brand. If it is an ibuprofen that is mixed with a form of narcotic pain medication, it can not be taken with Depakote.


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I have taken Seroquel with Ambien many times. They work well together for those nights I just can't get to sleep.


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No, depakote has no effect on anxiety.


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NO! Even though Topamax and Depakote are used to treat a lot of the same things, Depakote can cause interactions with Topamax. If your doctor prescribed both prescriptions to you, I would call a Walgreen's or CVS and ask a pharmacist. They usually have one specifically to answer questions about medications. But even the website for the makers of depakote and topamax said they shouldn't be taken together.


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