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It is unwise to begin mixing hydrocodone/APAP with any form of Excedrin, because they both contain acetaminophen. It it has been four to six hours after you have taken Excedrin, then you are following the instructions on the label and are not in any danger.

Excedrin contains 250mg of acetapinophen per pill.

Hydrocodone/APAP can contain anywhere from 325-750mg per pill. The most commonly prescribed dose has 500mg of acetaminophen in it.

You should not take more than 4000mg of acetaminophen in a day. If you are taking it daily, you should not take more than 3000mg. Per dose, you should not take more than 1000mg.

So, how unsafe it is depends on how much you have taken of each medication.

Always read the label, because many, many over the counter medications contain acetaminophen.

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15y ago
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12y ago

Yes, you can take them together. I would however, eat something small before taking them together. You can take up to: 4 ibuprofen/6 Exedrin Migraine tablets in a 24 hour period. If you need 8 Execdrin Migraine per day. That is the maximum. Usually up to 4 Ibuprofen 800 MG, is the norm. (And safe). Remember, Exedrin is basically all aspirin. It may not, but could give you a tummy ache. Be sure to drink a full 6 to 8 ounces of water with each dose.

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Q: Can you mix hydrocodone withAPAP and Excedrin Migraine?
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Because each patient's history is individual, it is vitally important that you check with your physician to find out what medications you can personally and safely mix with Excedrin Migraine. For appropriate diagnosis and treatment of Migraine and headache disorders, seek the help of a board certified headache specialist.


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